PMID- 24180694 OWN - NLM STAT- MEDLINE DCOM- 20140725 LR - 20171116 IS - 1936-086X (Electronic) IS - 1936-0851 (Linking) VI - 7 IP - 11 DP - 2013 Nov 26 TI - Field effect biosensing platform based on 2D alpha-MoO(3). PG - 9753-60 LID - 10.1021/nn403241f [doi] AB - Electrical-based biosensing platforms offer ease of fabrication and simple sensing solutions. Recently, two-dimensional (2D) semiconductors have been proven to be excellent for the fabrication of field effect transistors (FETs) due to their large transconductance, which can be efficiently used for developing sensitive bioplatforms. We present a 2D molybdenum trioxide (MoO3) FET based biosensing platform, using bovine serum albumin as a model protein. The conduction channel is a nanostructured film made of 2D alpha-MoO3 nanoflakes, with the majority of nanoflake thicknesses being equal to or less than 2.8 nm. The response time is impressively low (less than 10 s), which is due to the high permittivity of the 2D alpha-MoO3 nanoflakes. The system offers a competitive solution for future biosensing applications. FAU - Balendhran, Sivacarendran AU - Balendhran S AD - School of Electrical and Computer Engineering, RMIT University , Melbourne, Victoria, Australia. FAU - Walia, Sumeet AU - Walia S FAU - Alsaif, Manal AU - Alsaif M FAU - Nguyen, Emily P AU - Nguyen EP FAU - Ou, Jian Zhen AU - Ou JZ FAU - Zhuiykov, Serge AU - Zhuiykov S FAU - Sriram, Sharath AU - Sriram S FAU - Bhaskaran, Madhu AU - Bhaskaran M FAU - Kalantar-Zadeh, Kourosh AU - Kalantar-Zadeh K LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20131107 PL - United States TA - ACS Nano JT - ACS nano JID - 101313589 RN - 0 (Oxides) RN - 22FQ3F03YS (molybdenum trioxide) RN - 27432CM55Q (Serum Albumin, Bovine) RN - 81AH48963U (Molybdenum) SB - IM MH - Animals MH - *Biosensing Techniques MH - Cattle MH - Materials Testing MH - Microscopy, Atomic Force MH - Microscopy, Electron, Transmission MH - Molybdenum/*chemistry MH - *Nanostructures MH - Oxides/*chemistry MH - *Semiconductors MH - Serum Albumin, Bovine/chemistry MH - Spectrum Analysis, Raman MH - Surface Properties MH - Transistors, Electronic EDAT- 2013/11/05 06:00 MHDA- 2014/07/26 06:00 CRDT- 2013/11/05 06:00 PHST- 2013/11/05 06:00 [entrez] PHST- 2013/11/05 06:00 [pubmed] PHST- 2014/07/26 06:00 [medline] AID - 10.1021/nn403241f [doi] PST - ppublish SO - ACS Nano. 2013 Nov 26;7(11):9753-60. doi: 10.1021/nn403241f. Epub 2013 Nov 7.