PMID- 24182636
OWN - NLM
STAT- MEDLINE
DCOM- 20141007
LR  - 20220311
IS  - 1879-1360 (Electronic)
IS  - 0022-3999 (Linking)
VI  - 75
IP  - 5
DP  - 2013 Nov
TI  - Psychological distress is not associated with treatment failure in patients with 
      gastroesophageal reflux disease.
PG  - 462-6
LID - S0022-3999(13)00325-5 [pii]
LID - 10.1016/j.jpsychores.2013.08.008 [doi]
AB  - OBJECTIVE: Symptoms of anxiety and depression are common in patients with 
      gastroesophageal reflux disease (GERD). We aim to examine the relationship 
      between psychological distress and response to proton pump inhibitors (PPI). 
      METHODS: In this prospective study, GERD patients receiving PPI once or twice 
      daily were divided into 3 groups: responders to PPI once daily (group A, N=111), 
      non-responders to PPI once daily (group B, N=78) and non-responders to PPI twice 
      daily (group C, N=56). All patients completed demographic and clinical 
      questionnaires, Rome III Diagnostic Questionnaire for irritable bowel syndrome, 
      Hospital Anxiety and Depression Scale (HADS), Satisfaction with Life Scale (SWLS) 
      and the Gastroparesis Cardinal Symptom Index (GCSI) questionnaires. RESULTS: A 
      total of 245 patients (59.3% females, 52+/-17.2 years) participated in this study. 
      No differences were observed between groups with respect to age, sex, psychiatric 
      medications or pre-existing major depression. Anxiety (HADS-anxiety>7) was seen 
      in 32%, 31% and 34% of groups A, B and C, respectively (p=ns). Depression 
      (HADS-depression>7) was present in 30%, 31% and 21% of groups A, B and C, 
      respectively (p=ns). Global satisfaction with life (SWLS>20) was present in 63% 
      of group C patients, compared to 78% of group A and 78% of group B (p=0.04, 
      p=0.05, respectively). GCSI scores (mean+/-SD) were 11.1+/-9.2, 14.07+/-8.5 and 
      16.3+/-10.4, for groups A, B and C, respectively (p=0.002). GCSI correlated 
      significantly with HADS-anxiety (r=0.20, p=0.002) and SWLS (r=-0.2, p=0.01). 
      CONCLUSION: Lack of response to PPI was associated with lower life satisfaction 
      but not anxiety or depression. Symptoms suggestive of gastroparesis were 
      associated with anxiety and low satisfaction with life in patients with GERD.
CI  - (c) 2013.
FAU - Boltin, Doron
AU  - Boltin D
AD  - Department of Gastroenterology, Rabin Medical Center, Beilinson Campus, Petach 
      Tikva, Israel. Electronic address: dboltin@gmail.com.
FAU - Boaz, Mona
AU  - Boaz M
FAU - Aizic, Shoshana
AU  - Aizic S
FAU - Sperber, Ami
AU  - Sperber A
FAU - Fass, Ronnie
AU  - Fass R
FAU - Niv, Yaron
AU  - Niv Y
FAU - Dickman, Ram
AU  - Dickman R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130827
PL  - England
TA  - J Psychosom Res
JT  - Journal of psychosomatic research
JID - 0376333
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anxiety/*etiology
MH  - Depression/*etiology
MH  - Female
MH  - Gastroesophageal Reflux/*drug therapy/*psychology
MH  - Humans
MH  - Irritable Bowel Syndrome/psychology
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Proton Pump Inhibitors/*administration & dosage
MH  - Stress, Psychological/*etiology
MH  - Surveys and Questionnaires
MH  - Treatment Failure
OTO - NOTNLM
OT  - Anxiety
OT  - Depression
OT  - Functional gastrointestinal disease
OT  - Gastroesophageal reflux disease
OT  - Heartburn
OT  - Proton pump inhibitor
EDAT- 2013/11/05 06:00
MHDA- 2014/10/08 06:00
CRDT- 2013/11/05 06:00
PHST- 2013/07/07 00:00 [received]
PHST- 2013/08/14 00:00 [revised]
PHST- 2013/08/17 00:00 [accepted]
PHST- 2013/11/05 06:00 [entrez]
PHST- 2013/11/05 06:00 [pubmed]
PHST- 2014/10/08 06:00 [medline]
AID - S0022-3999(13)00325-5 [pii]
AID - 10.1016/j.jpsychores.2013.08.008 [doi]
PST - ppublish
SO  - J Psychosom Res. 2013 Nov;75(5):462-6. doi: 10.1016/j.jpsychores.2013.08.008. 
      Epub 2013 Aug 27.