PMID- 24182654
OWN - NLM
STAT- MEDLINE
DCOM- 20140701
LR  - 20131104
IS  - 1776-2588 (Electronic)
IS  - 0761-8425 (Linking)
VI  - 30
IP  - 8
DP  - 2013 Oct
TI  - [Pulmonary fungal infection in patients with AIDS].
PG  - 682-95
LID - S0761-8425(13)00065-X [pii]
LID - 10.1016/j.rmr.2013.02.005 [doi]
AB  - Fungal infections are the most common opportunistic infections (OI) occurring 
      during the course of HIV infection, though their incidence has decreased 
      dramatically with the introduction of highly active antiretroviral therapy 
      (cART). Most cases occur in untreated patients, noncompliant patients or patients 
      whose multiple antiretroviral regimens have failed and they are a good marker of 
      the severity of cellular immunodepression. Pneumocystis jiroveci pneumonia is the 
      second most frequent OI in France and cryptococcosis remains a major problem in 
      the Southern Hemisphere. With the increase in travel, imported endemic fungal 
      infection can occur and may mimic other infections, notably tuberculosis. Fungal 
      infections often have a pulmonary presentation but an exhaustive search for 
      dissemination should be made in patients infected with HIV, at least those at an 
      advanced stage of immune deficiency. Introduction of cART in combination with 
      anti-fungal treatment depends on the risk of AIDS progression and on the risk of 
      cumulative toxicity and the immune reconstitution inflammatory syndrome (IRIS) if 
      introduced too early. Fungal infections in HIV infected patients remain a problem 
      in the cART era. IRIS can complicate the management and requires an optimised 
      treatment regime.
CI  - Copyright (c) 2013. Published by Elsevier Masson SAS.
FAU - Denis, B
AU  - Denis B
AD  - Service des maladies infectieuses et tropicales, centre d'infectiologie 
      Necker-Pasteur, universite Paris Descartes, hopital Necker-Enfants-Malades, 149, 
      rue de Sevres, 75743 Paris cedex 15, France.
FAU - Lortholary, O
AU  - Lortholary O
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Infections fongiques pulmonaires chez les patients seropositifs pour le VIH.
DEP - 20130328
PL  - France
TA  - Rev Mal Respir
JT  - Revue des maladies respiratoires
JID - 8408032
SB  - IM
MH  - AIDS-Related Opportunistic Infections/*etiology/microbiology/therapy
MH  - Acquired Immunodeficiency Syndrome/*complications/drug therapy/microbiology
MH  - Antiretroviral Therapy, Highly Active
MH  - Humans
MH  - Immune Tolerance/drug effects
MH  - Lung Diseases, Fungal/*etiology/microbiology/therapy
MH  - Mycoses/classification/etiology/therapy
MH  - Pulmonary Aspergillosis/etiology/therapy
OTO - NOTNLM
OT  - Cryptococcose
OT  - Cryptococcosis
OT  - Endemic mycoses
OT  - HIV
OT  - IRIS
OT  - Mycoses endemiques
OT  - Pneumocystis jiroveci pneumonia
OT  - Pneumocystose
OT  - VIH
EDAT- 2013/11/05 06:00
MHDA- 2014/07/02 06:00
CRDT- 2013/11/05 06:00
PHST- 2011/11/03 00:00 [received]
PHST- 2013/02/07 00:00 [accepted]
PHST- 2013/11/05 06:00 [entrez]
PHST- 2013/11/05 06:00 [pubmed]
PHST- 2014/07/02 06:00 [medline]
AID - S0761-8425(13)00065-X [pii]
AID - 10.1016/j.rmr.2013.02.005 [doi]
PST - ppublish
SO  - Rev Mal Respir. 2013 Oct;30(8):682-95. doi: 10.1016/j.rmr.2013.02.005. Epub 2013 
      Mar 28.