PMID- 24182674
OWN - NLM
STAT- MEDLINE
DCOM- 20140812
LR  - 20131118
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 170
IP  - 1
DP  - 2013 Dec 5
TI  - The HERO-2 ECG sub-studies in patients with ST elevation myocardial infarction: 
      implications for clinical practice.
PG  - 17-23
LID - S0167-5273(13)01822-6 [pii]
LID - 10.1016/j.ijcard.2013.10.008 [doi]
AB  - The ECG studies of the international HERO-2 trial in ST elevation myocardial 
      infarction (STEMI) patients evaluated the prognostic value of ECGs systematically 
      recorded at baseline and at 60-min post-administration of fibrinolytic therapy. 
      Patients were overall managed conservatively with a low percentage undergoing 
      angiography. Many of the analyses were pre-specified. While modern management of 
      STEMI has improved, particularly with the widespread use of primary angioplasty, 
      the HERO-2 database documents the prognostic relationship between ECG findings in 
      STEMI patients managed with fibrinolytic therapy and 30-day mortality. This 
      article describes the history of the HERO-2 ECG sub-studies, discloses new 
      information in the project development and summarizes its findings. The strength 
      of having serial ECG recordings is discussed as is the weakness of lacking 
      angiographic correlation. The paper discusses with take-home points (Table 1) the 
      prognostic implications of bundle branch blocks, QRS duration, Q waves in infarct 
      leads, V1 ST elevation during inferior STEMI, lead aVR ST changes and new ST 
      depression in the infarct leads after fibrinolysis. With the ever increasing 
      emphasis on early (including pre-hospital) therapies for STEMI, a diagnosis based 
      on the 12-lead ECG, the current summary article provides helpful hints to fully 
      extract ECG information, and a vision for future STEMI diagnosis and management.
CI  - (c) 2013.
FAU - Wong, Cheuk-Kit
AU  - Wong CK
AD  - Dunedin School of Medicine, University of Otago, Dunedin, New Zealand. Electronic 
      address: cheuk-kit.wong@healthotago.co.nz.
FAU - White, Harvey D
AU  - White HD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20131011
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - 0 (Anticoagulants)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Anticoagulants/administration & dosage
MH  - Bundle-Branch Block/diagnosis/physiopathology/therapy
MH  - Electrocardiography/*methods
MH  - Heparin/administration & dosage
MH  - Humans
MH  - Internationality
MH  - Myocardial Infarction/diagnosis/*physiopathology/*therapy
MH  - Randomized Controlled Trials as Topic/methods
OTO - NOTNLM
OT  - 30-day mortality
OT  - ECG
OT  - Fibrinolysis
OT  - STEMI
EDAT- 2013/11/05 06:00
MHDA- 2014/08/13 06:00
CRDT- 2013/11/05 06:00
PHST- 2013/05/23 00:00 [received]
PHST- 2013/07/31 00:00 [revised]
PHST- 2013/10/05 00:00 [accepted]
PHST- 2013/11/05 06:00 [entrez]
PHST- 2013/11/05 06:00 [pubmed]
PHST- 2014/08/13 06:00 [medline]
AID - S0167-5273(13)01822-6 [pii]
AID - 10.1016/j.ijcard.2013.10.008 [doi]
PST - ppublish
SO  - Int J Cardiol. 2013 Dec 5;170(1):17-23. doi: 10.1016/j.ijcard.2013.10.008. Epub 
      2013 Oct 11.