PMID- 24182794
OWN - NLM
STAT- MEDLINE
DCOM- 20140616
LR  - 20131104
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 45
IP  - 9
DP  - 2013 Nov
TI  - Association of de novo human leukocyte antigen and major histocompatibility 
      complex class I chain-related gene-A antibodies and proteinuria with graft 
      survival 5 years after renal transplantation.
PG  - 3249-53
LID - S0041-1345(13)00772-0 [pii]
LID - 10.1016/j.transproceed.2013.08.029 [doi]
AB  - BACKGROUND: Association of de novo human leukocyte antigen (HLA) and major 
      histocompatibility complex class I chain-related gene-A (MICA) antibodies and 
      proteinuria with graft survival 5 years after renal transplantation. De novo 
      presence of HLA and MICA antibodies after renal transplantation is associated 
      with poor graft survival. Proteinuria after transplantation is also considered a 
      risk factor for premature graft loss. In this study, we investigated the 
      association of de novo HLA and MICA antibodies on proteinuria after renal 
      transplantation and the association of proteinuria and de novo antibodies with 
      graft survival. METHODS: We enrolled 275 patients without preexisting HLA and 
      MICA antibodies followed for >5 years after renal transplantation. All donor 
      organs were from living-related donors or from an organ donation program. HLA and 
      MICA antibodies were detected by the Luminex method. Patients with proteinuria 
      (>150 mg/d) underwent intermittent 24-hour proteinuria examination. RESULTS: The 
      frequencies of de novo HLA and MICA antibody 5 years after transplantation were 
      25.8% and 12%, respectively. In total, 26.5% of patients had proteinuria at the 
      5-year follow-up. De novo HLA antibody was associated with increased proteinuria 
      after transplantation (relative risk, 3.12). HLA antibody and proteinuria were 
      both associated with poor 5-year graft survival (P = .027 and P = .006, 
      respectively). CONCLUSION: De novo HLA and MICA antibodies and proteinuria after 
      renal transplantation are all associated with poor graft survival. De novo HLA 
      antibody is independent risk factor for posttransplant proteinuria, and 
      proteinuria affects the association of de novo antibodies with decreased graft 
      survival after transplantation.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Zhang, L-W
AU  - Zhang LW
AD  - Department of Organ Transplantation, Shandong University, Qilu Hospital, 
      Shandong, China.
FAU - Peng, Z-G
AU  - Peng ZG
FAU - Xian, W-H
AU  - Xian WH
FAU - Cui, X-Q
AU  - Cui XQ
FAU - Sun, H-B
AU  - Sun HB
FAU - Li, E-G
AU  - Li EG
FAU - Geng, L-N
AU  - Geng LN
FAU - Zhao, P
AU  - Zhao P
FAU - Tian, J
AU  - Tian J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (Autoantibodies)
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adult
MH  - Autoantibodies/*immunology
MH  - Female
MH  - *Graft Survival
MH  - HLA Antigens/*immunology
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Humans
MH  - *Kidney Transplantation
MH  - Male
MH  - Proteinuria/*diagnosis
EDAT- 2013/11/05 06:00
MHDA- 2014/06/17 06:00
CRDT- 2013/11/05 06:00
PHST- 2012/07/21 00:00 [received]
PHST- 2013/07/15 00:00 [revised]
PHST- 2013/08/16 00:00 [accepted]
PHST- 2013/11/05 06:00 [entrez]
PHST- 2013/11/05 06:00 [pubmed]
PHST- 2014/06/17 06:00 [medline]
AID - S0041-1345(13)00772-0 [pii]
AID - 10.1016/j.transproceed.2013.08.029 [doi]
PST - ppublish
SO  - Transplant Proc. 2013 Nov;45(9):3249-53. doi: 10.1016/j.transproceed.2013.08.029.