PMID- 24183038
OWN - NLM
STAT- MEDLINE
DCOM- 20140130
LR  - 20131104
IS  - 1000-503X (Print)
IS  - 1000-503X (Linking)
VI  - 35
IP  - 5
DP  - 2013 Oct
TI  - [Changes in subcortical white matter and corpus callosum volumes in patients with 
      type 2 diabetes mellitus].
PG  - 503-14
LID - 10.3881/j.issn.1000-503X.2013.05.005 [doi]
AB  - OBJECTIVE: To evaluate the changes in subcortical white matter and corpus 
      callosum volumes in patients with type 2 diabetes mellitus (T2DM). METHODS: High 
      resolution three-dimensional T1-weighted fast spoiled gradient recalled echo 
      magnetic resonance images were obtained from 16 T2DM patients and 16 normal 
      controls, and 11 T2DM patients also received the same magnetic resonance imaging 
      scans after insulin therapy for 1 year. Volumetric analysis was performed and 
      analysis of covariance and paired t test were applied. RESULTS: A lower volume 
      was demonstrated in T2DM patients than that in the normal controls in bilateral 
      caudal middle frontal lobe, bilateral pars opercularis, right inferior parietal 
      lobe, right inferior temporal lobe, right middle temporal lobe, and left 
      transverse temporal lobe (all P<0.05). After insulin therapy for 1 year, the 
      increased subcortical white matter of brain regions were demonstrated in left 
      medial orbitofrontal lobe, right caudal middle frontal lobe, right inferior 
      parietal lobe, right lingual lobe, right inferior temporal lobe, right middle 
      temporal lobe, left transverse temporal lobe, left entorhinal lobe and left 
      insular lobe at the follow-up level in T2DM patients compared with baseline level 
      (P<0.05). The decreased volumes of subcortical white matter were observed in the 
      bilateral paracentral lobe, right superior forntal lobe and right precuneus lobe 
      in T2DM patients on insulin therapy for 1 year (P<0.05). A decreased trend of 
      subcortical white matter was involved in corpus callosum (P>0.05) and a 
      significant decreased volume was demonstrated in the middle posterior part of 
      corpus callosum after insulin therapy for 1 year(P<0.05). CONCLUSIONS: T2DM 
      patients have decreased subcortical white matter of multiple brain regions, and 
      the atrophy of subcortical white matter can be improved by the insulin therapy. 
      The volume analysis of subcortical white matter is a simple and effective tool 
      for the evaluation of white matter damage in T2DM patients.
FAU - Chen, Zhi-Ye
AU  - Chen ZY
AD  - Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China.
FAU - Li, Jin-Feng
AU  - Li JF
FAU - Sun, Jie
AU  - Sun J
FAU - Ma, Lin
AU  - Ma L
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Yi Xue Ke Xue Yuan Xue Bao
JT  - Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
JID - 8006230
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - Corpus Callosum/*pathology
MH  - Diabetes Mellitus, Type 2/*pathology
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Plethysmography
EDAT- 2013/11/05 06:00
MHDA- 2014/01/31 06:00
CRDT- 2013/11/05 06:00
PHST- 2013/11/05 06:00 [entrez]
PHST- 2013/11/05 06:00 [pubmed]
PHST- 2014/01/31 06:00 [medline]
AID - 10.3881/j.issn.1000-503X.2013.05.005 [doi]
PST - ppublish
SO  - Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2013 Oct;35(5):503-14. doi: 
      10.3881/j.issn.1000-503X.2013.05.005.