PMID- 24183823
OWN - NLM
STAT- MEDLINE
DCOM- 20140225
LR  - 20131224
IS  - 1872-7786 (Electronic)
IS  - 0009-2797 (Linking)
VI  - 207
DP  - 2014 Jan 25
TI  - Hematological, biochemical and enzymological responses in an Indian major carp 
      Labeo rohita induced by sublethal concentration of waterborne selenite exposure.
PG  - 67-73
LID - S0009-2797(13)00272-X [pii]
LID - 10.1016/j.cbi.2013.10.018 [doi]
AB  - Selenium (Se) pollution in aquatic ecosystem is an environmental issue throughout 
      the world. Elevated concentrations of inorganic Se from agricultural and 
      industrial processes may cause adverse biological effects in aquatic organisms 
      such as fish. In the present study, Labeo rohita an Indian major carp were 
      exposed to sublethal concentration of Se (sodium selenite) for 35days and certain 
      hematological, biochemical and enzymological parameters were estimated. The 
      median lethal concentration of waterborne sodium selenite (Na2SeO3) to L. rohita 
      was found to be 23.89mgL(-1) for 96h. During sublethal (2.38mgL(-1)) treatment, 
      hematological and biochemical parameters such as hemoglobin (Hb) (except 14th 
      day), hematocrit (Hct), erythrocyte (RBC) count and protein levels were found to 
      be decreased in Se treated fish whereas leucocyte (WBC) count and glucose level 
      increased in Se treated fish throughout the study period. The enzymatic 
      parameters such as glutamate oxaloacetate transaminase (GOT), glutamate pyruvate 
      transaminase (GPT) and lactate dehydrogenase (LDH) activities were found to be 
      increased in liver of Se treated fish L. rohita. A biphasic response was observed 
      in the value of mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) 
      and mean corpuscular hemoglobin concentration (MCHC). The alterations of these 
      parameters can be used as suitable biomarkers in monitoring of selenium in the 
      aquatic environment and to protect aquatic life.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Ramesh, Mathan
AU  - Ramesh M
AD  - Unit of Toxicology, Department of Zoology, School of Life Sciences, Bharathiar 
      University, Coimbatore 641046, Tamil Nadu, India.
FAU - Sankaran, Marimuthu
AU  - Sankaran M
AD  - Unit of Toxicology, Department of Zoology, School of Life Sciences, Bharathiar 
      University, Coimbatore 641046, Tamil Nadu, India.
FAU - Veera-Gowtham, Velusami
AU  - Veera-Gowtham V
AD  - Unit of Toxicology, Department of Zoology, School of Life Sciences, Bharathiar 
      University, Coimbatore 641046, Tamil Nadu, India.
FAU - Poopal, Rama Krishnan
AU  - Poopal RK
AD  - Unit of Toxicology, Department of Zoology, School of Life Sciences, Bharathiar 
      University, Coimbatore 641046, Tamil Nadu, India. Electronic address: 
      poopalramakrishanan@ymail.com.
LA  - eng
PT  - Journal Article
DEP - 20131030
PL  - Ireland
TA  - Chem Biol Interact
JT  - Chemico-biological interactions
JID - 0227276
RN  - 0 (Blood Glucose)
RN  - 0 (Blood Proteins)
RN  - 0 (Enzymes)
RN  - 0 (Water Pollutants, Chemical)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
RN  - EC 2.6.1.- (Aspartate Aminotransferase, Cytoplasmic)
RN  - EC 2.6.1.- (Transaminases)
RN  - HIW548RQ3W (Sodium Selenite)
SB  - IM
MH  - Animals
MH  - Aspartate Aminotransferase, Cytoplasmic/metabolism
MH  - Blood Glucose/metabolism
MH  - Blood Proteins/metabolism
MH  - Carps/*blood/*metabolism
MH  - *Environmental Exposure
MH  - Enzymes/*metabolism
MH  - India
MH  - L-Lactate Dehydrogenase/metabolism
MH  - Sodium Selenite/*toxicity
MH  - Transaminases
MH  - Water Pollutants, Chemical/*toxicity
OTO - NOTNLM
OT  - Biochemical
OT  - Enzymological parameters
OT  - Hematological
OT  - Labeo rohita
OT  - Selenium
OT  - Sublethal toxicity
EDAT- 2013/11/05 06:00
MHDA- 2014/02/26 06:00
CRDT- 2013/11/05 06:00
PHST- 2013/07/06 00:00 [received]
PHST- 2013/09/28 00:00 [revised]
PHST- 2013/10/22 00:00 [accepted]
PHST- 2013/11/05 06:00 [entrez]
PHST- 2013/11/05 06:00 [pubmed]
PHST- 2014/02/26 06:00 [medline]
AID - S0009-2797(13)00272-X [pii]
AID - 10.1016/j.cbi.2013.10.018 [doi]
PST - ppublish
SO  - Chem Biol Interact. 2014 Jan 25;207:67-73. doi: 10.1016/j.cbi.2013.10.018. Epub 
      2013 Oct 30.