PMID- 24185608
OWN - NLM
STAT- MEDLINE
DCOM- 20140219
LR  - 20180126
IS  - 1471-6771 (Electronic)
IS  - 0007-0912 (Linking)
VI  - 112
IP  - 1
DP  - 2014 Jan
TI  - Bispectral index values and propofol concentrations at loss and return of 
      consciousness in patients with frontal brain tumours and control patients.
PG  - 110-7
LID - 10.1093/bja/aet342 [doi]
AB  - BACKGROUND: The influence of frontal brain tumours on bispectral index (BIS) 
      measurements and propofol requirements is unknown. The primary aim of our study 
      was to determine whether BIS values recorded at loss and return of consciousness 
      (LOC and ROC, respectively) differ between patients with unilateral frontal brain 
      tumours and control patients. Secondary goals were to compare propofol 
      requirements for LOC and to determine whether there were significant 
      inter-hemispheric differences between BIS values in tumour and control patients. 
      METHODS: We enrolled 20 patients with a frontal brain tumour and 20 control 
      patients. Bilateral BIS measurements were done during induction of propofol 
      anaesthesia, during recovery of consciousness, and during a second induction of 
      anaesthesia. The isolated-forearm test was used to determine the moments of LOC1, 
      ROC, and LOC2. Arterial blood samples were obtained every 4 min for determination 
      of measured propofol concentrations. RESULTS: The median BIS values recorded at 
      LOC1, ROC, and LOC2 did not differ between the groups. There were no significant 
      inter-hemispheric differences in BIS in tumour and control patients. The median 
      [inter-quartile range (IQR)] total propofol doses at LOC1 were 82 (75-92) and 78 
      (68-91) mg in tumour and control patients, respectively. The median (IQR) 
      measured plasma propofol concentrations at LOC1 were 12 (9-14) and 13 (11-15) microg 
      ml(-1) in the tumour and control groups, respectively. CONCLUSIONS: The presence 
      of a frontal brain tumour did not affect ipsilateral BIS values, and so need not 
      influence the placement of unilateral BIS electrodes if BIS monitoring is used to 
      titrate propofol anaesthesia.
FAU - Sahinovic, M M
AU  - Sahinovic MM
AD  - Department of Anesthesiology,.
FAU - Beese, U
AU  - Beese U
FAU - Heeremans, E H
AU  - Heeremans EH
FAU - Kalmar, A
AU  - Kalmar A
FAU - van Amsterdam, K
AU  - van Amsterdam K
FAU - Steenbakkers, R J H M
AU  - Steenbakkers RJ
FAU - Kuiper, H
AU  - Kuiper H
FAU - Spanjersberg, R
AU  - Spanjersberg R
FAU - Groen, R J M
AU  - Groen RJ
FAU - Struys, M M R F
AU  - Struys MM
FAU - Absalom, A R
AU  - Absalom AR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131031
PL  - England
TA  - Br J Anaesth
JT  - British journal of anaesthesia
JID - 0372541
RN  - 0 (Anesthetics, Intravenous)
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anesthetics, Intravenous/*blood
MH  - Brain Neoplasms/*physiopathology/surgery
MH  - Consciousness/*physiology
MH  - *Electroencephalography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Propofol/*blood
OTO - NOTNLM
OT  - brain tumour
OT  - depth of anaesthesia
OT  - monitoring, bispectral index
OT  - pharmacology, propofol
EDAT- 2013/11/05 06:00
MHDA- 2014/02/20 06:00
CRDT- 2013/11/05 06:00
PHST- 2013/11/05 06:00 [entrez]
PHST- 2013/11/05 06:00 [pubmed]
PHST- 2014/02/20 06:00 [medline]
AID - S0007-0912(17)31976-1 [pii]
AID - 10.1093/bja/aet342 [doi]
PST - ppublish
SO  - Br J Anaesth. 2014 Jan;112(1):110-7. doi: 10.1093/bja/aet342. Epub 2013 Oct 31.