PMID- 24185909
OWN - NLM
STAT- MEDLINE
DCOM- 20140603
LR  - 20211021
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 14
IP  - 11
DP  - 2013 Oct 31
TI  - The effect of different intensities of treadmill exercise on cognitive function 
      deficit following a severe controlled cortical impact in rats.
PG  - 21598-612
LID - 10.3390/ijms141121598 [doi]
AB  - Exercise has been proposed for the treatment of traumatic brain injury (TBI). 
      However, the proper intensity of exercise in the early phase following a severe 
      TBI is largely unknown. To compare two different treadmill exercise intensities 
      on the cognitive function following a severe TBI in its early phase, rats 
      experienced a controlled cortical impact (CCI) and were forced to treadmill 
      exercise for 14 days. The results revealed that the rats in the low intensity 
      exercise group had a shorter latency to locate a platform and a significantly 
      better improvement in spatial memory in the Morris water maze (MWM) compared to 
      the control group (p < 0.05). The high intensity exercise group showed a longer 
      latency and a mild improvement in spatial memory compared to the control group 
      rats in the MWM; however, this difference was not statistically significant (p > 
      0.05). The brain-derived neurotrophic factor (BDNF) and p-CREB protein levels in 
      the contralateral hippocampus were increased significantly in the low intensity 
      exercise group. Our results suggest that 2 weeks of low intensity of treadmill 
      exercise is beneficial for improving cognitive function and increasing 
      hippocampal BDNF expression after a severe TBI in its early phase.
FAU - Shen, Xiafeng
AU  - Shen X
AD  - Department of Rehabilitation, Huashan Hospital, Fudan University, Shanghai 
      200040, China. drliap@163.com.
FAU - Li, Aiping
AU  - Li A
FAU - Zhang, Yuling
AU  - Zhang Y
FAU - Dong, Xiaomin
AU  - Dong X
FAU - Shan, Tian
AU  - Shan T
FAU - Wu, Yi
AU  - Wu Y
FAU - Jia, Jie
AU  - Jia J
FAU - Hu, Yongshan
AU  - Hu Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131031
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain Injuries/pathology/*therapy
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cognition Disorders/metabolism/physiopathology/*therapy
MH  - *Exercise
MH  - Humans
MH  - Maze Learning
MH  - Memory/physiology
MH  - *Physical Conditioning, Animal
MH  - Rats
PMC - PMC3856023
EDAT- 2013/11/05 06:00
MHDA- 2014/06/04 06:00
PMCR- 2013/11/01
CRDT- 2013/11/05 06:00
PHST- 2013/08/30 00:00 [received]
PHST- 2013/10/12 00:00 [revised]
PHST- 2013/10/17 00:00 [accepted]
PHST- 2013/11/05 06:00 [entrez]
PHST- 2013/11/05 06:00 [pubmed]
PHST- 2014/06/04 06:00 [medline]
PHST- 2013/11/01 00:00 [pmc-release]
AID - ijms141121598 [pii]
AID - ijms-14-21598 [pii]
AID - 10.3390/ijms141121598 [doi]
PST - epublish
SO  - Int J Mol Sci. 2013 Oct 31;14(11):21598-612. doi: 10.3390/ijms141121598.