PMID- 24186772 OWN - NLM STAT- MEDLINE DCOM- 20151021 LR - 20220309 IS - 1522-2594 (Electronic) IS - 0740-3194 (Print) IS - 0740-3194 (Linking) VI - 72 IP - 3 DP - 2014 Sep TI - 3D late gadolinium enhancement in a single prolonged breath-hold using supplemental oxygenation and hyperventilation. PG - 850-7 LID - 10.1002/mrm.24969 [doi] AB - PURPOSE: To evaluate the feasibility of three-dimensional (3D) single breath-hold late gadolinium enhancement (LGE) of the left ventricle (LV) using supplemental oxygen and hyperventilation and compressed-sensing acceleration. METHODS: Breath-hold metrics [breath-hold duration, diaphragmatic/LV position drift, and maximum variation of R wave to R wave (RR) interval] without and with supplemental oxygen and hyperventilation were assessed in healthy adult subjects using a real-time single shot acquisition. Ten healthy subjects and 13 patients then underwent assessment of the proposed 3D breath-hold LGE acquisition (field of view = 320 x 320 x 100 mm(3) , resolution = 1.6 x 1.6 x 5.0 mm(3) , acceleration rate of 4) and a free-breathing acquisition with right hemidiaphragm navigator (NAV) respiratory gating. Semiquantitative grading of overall image quality, motion artifact, myocardial nulling, and diagnostic value was performed by consensus of two blinded observers. RESULTS: Supplemental oxygenation and hyperventilation increased the breath-hold duration (35 +/- 11 s to 58 +/- 21 s; P < 0.0125) without significant impact on diaphragmatic/LV position drift or maximum variation of RR interval (both P > 0.01). LGE images were of similar quality when compared with free-breathing acquisitions, but with reduced total scan time (85 +/- 22 s to 35 +/- 6 s; P < 0.001). CONCLUSIONS: Supplemental oxygenation and hyperventilation allow for prolonged breath-holding and enable single breath-hold 3D accelerated LGE with similar image quality as free breathing with NAV. CI - Copyright (c) 2013 Wiley Periodicals, Inc. FAU - Roujol, Sebastien AU - Roujol S AD - Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA. FAU - Basha, Tamer A AU - Basha TA FAU - Akcakaya, Mehmet AU - Akcakaya M FAU - Foppa, Murilo AU - Foppa M FAU - Chan, Raymond H AU - Chan RH FAU - Kissinger, Kraig V AU - Kissinger KV FAU - Goddu, Beth AU - Goddu B FAU - Berg, Sophie AU - Berg S FAU - Manning, Warren J AU - Manning WJ FAU - Nezafat, Reza AU - Nezafat R LA - eng GR - R01 EB008743/EB/NIBIB NIH HHS/United States GR - R01EB008743-01A2/EB/NIBIB NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20131015 PL - United States TA - Magn Reson Med JT - Magnetic resonance in medicine JID - 8505245 RN - 0 (Contrast Media) RN - 0 (Organometallic Compounds) RN - 15G12L5X8K (gadobenic acid) RN - 6HG8UB2MUY (Meglumine) RN - S88TT14065 (Oxygen) SB - IM MH - Adult MH - Artifacts MH - *Breath Holding MH - Cardiac-Gated Imaging Techniques MH - Contrast Media/administration & dosage MH - Feasibility Studies MH - Female MH - Healthy Volunteers MH - Humans MH - *Hyperventilation MH - Imaging, Three-Dimensional/*methods MH - Male MH - Meglumine/administration & dosage/*analogs & derivatives MH - Organometallic Compounds/*administration & dosage MH - Oxygen/*administration & dosage PMC - PMC3988269 MID - NIHMS529565 OTO - NOTNLM OT - 3D acquisition OT - acceleration techniques OT - breath-hold OT - compressed sensing OT - hyperventilation OT - late gadolinium enhancement OT - left ventricle OT - myocardial viability EDAT- 2013/11/05 06:00 MHDA- 2015/10/22 06:00 PMCR- 2015/09/01 CRDT- 2013/11/05 06:00 PHST- 2013/03/26 00:00 [received] PHST- 2013/08/28 00:00 [revised] PHST- 2013/09/04 00:00 [accepted] PHST- 2013/11/05 06:00 [entrez] PHST- 2013/11/05 06:00 [pubmed] PHST- 2015/10/22 06:00 [medline] PHST- 2015/09/01 00:00 [pmc-release] AID - 10.1002/mrm.24969 [doi] PST - ppublish SO - Magn Reson Med. 2014 Sep;72(3):850-7. doi: 10.1002/mrm.24969. Epub 2013 Oct 15.