PMID- 24188865
OWN - NLM
STAT- MEDLINE
DCOM- 20150511
LR  - 20181202
IS  - 1879-0887 (Electronic)
IS  - 0167-8140 (Linking)
VI  - 110
IP  - 3
DP  - 2014 Mar
TI  - Doses to head and neck normal tissues for early stage Hodgkin lymphoma after 
      involved node radiotherapy.
PG  - 441-7
LID - S0167-8140(13)00522-7 [pii]
LID - 10.1016/j.radonc.2013.09.027 [doi]
AB  - PURPOSE: To evaluate dose plans for head and neck organs at risk (OARs) for 
      classical Hodgkin lymphoma (HL) patients using involved node radiotherapy (INRT) 
      delivered as 3D conformal radiotherapy (3DCRT), volumetric modulated arc therapy 
      (VMAT), and intensity modulated proton therapy (PT), in comparison to the past 
      mantle field (MF). MATERIALS AND METHODS: Data from 37 patients with cervical 
      lymph node involvement were used. All patients originally received chemotherapy 
      followed by 3DCRT-INRT (30.6 Gy). A VMAT-INRT, PT-INRT (both 30.6 Gy), and a MF 
      plan (36 Gy) were simulated. Doses to head and neck OARs were compared with 
      cumulative DVHs and repeated measures ANOVA. RESULTS: The estimated median mean 
      doses were 15.3, 19.3, 15.4, and 37.3 Gy (thyroid), 10.9, 12.0, 7.9, and 34.5 Gy 
      (neck muscles), 2.3, 11.1, 1.8, and 37.1 Gy (larynx), 1.7, 5.1, 1.3, and 23.8 Gy 
      (pharynx), 0.5, 0.8, 0.01, and 32.3 Gy (ipsilateral parotid), and 2.4, 3.8, 0.7, 
      and 34.7 Gy (ipsilateral submandibular) with 3DCRT, VMAT, PT, and MF (all 
      p<0.0001), respectively. CONCLUSION: The use of INRT significantly lowered the 
      estimated radiation dose to the head and neck OARs. VMAT appeared suboptimal 
      compared to 3DCRT and PT, and for some patients, PT offered an additional gain.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Maraldo, M V
AU  - Maraldo MV
AD  - Department of Radiation Oncology, Albert Einstein College of Medicine of Yeshiva 
      University, NY, USA. Electronic address: dra.maraldo@gmail.com.
FAU - Brodin, N P
AU  - Brodin NP
AD  - Department of Radiation Oncology, Albert Einstein College of Medicine of Yeshiva 
      University, NY, USA.
FAU - Aznar, M C
AU  - Aznar MC
AD  - Department of Radiation Oncology, Albert Einstein College of Medicine of Yeshiva 
      University, NY, USA; Niels Bohr Institute, Faculty of Sciences, University of 
      Copenhagen, Denmark.
FAU - Vogelius, I R
AU  - Vogelius IR
AD  - Department of Radiation Oncology, Albert Einstein College of Medicine of Yeshiva 
      University, NY, USA.
FAU - Munck Af Rosenschold, P
AU  - Munck Af Rosenschold P
AD  - Department of Radiation Oncology, Albert Einstein College of Medicine of Yeshiva 
      University, NY, USA; Niels Bohr Institute, Faculty of Sciences, University of 
      Copenhagen, Denmark.
FAU - Petersen, P M
AU  - Petersen PM
AD  - Department of Radiation Oncology, Albert Einstein College of Medicine of Yeshiva 
      University, NY, USA; Department of Oncology, Rigshospitalet, University of 
      Copenhagen, Denmark; Department of Hematology, Rigshospitalet, University of 
      Copenhagen, Denmark.
FAU - Specht, L
AU  - Specht L
AD  - Department of Radiation Oncology, Albert Einstein College of Medicine of Yeshiva 
      University, NY, USA; Department of Oncology, Rigshospitalet, University of 
      Copenhagen, Denmark; Department of Hematology, Rigshospitalet, University of 
      Copenhagen, Denmark.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131101
PL  - Ireland
TA  - Radiother Oncol
JT  - Radiotherapy and oncology : journal of the European Society for Therapeutic 
      Radiology and Oncology
JID - 8407192
SB  - IM
MH  - Adult
MH  - Female
MH  - Head/*radiation effects
MH  - Hodgkin Disease/pathology/*radiotherapy
MH  - Humans
MH  - Lymph Nodes/pathology/*radiation effects
MH  - Male
MH  - Middle Aged
MH  - Neck/*radiation effects
MH  - Neoplasm Staging
MH  - Organs at Risk
MH  - Proton Therapy
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/adverse effects
MH  - Radiotherapy, Conformal/adverse effects
MH  - Radiotherapy, Intensity-Modulated/adverse effects
OTO - NOTNLM
OT  - 3DCRT
OT  - Hodgkin lymphoma
OT  - Normal tissues
OT  - Proton therapy
OT  - Radiotherapy
OT  - VMAT
EDAT- 2013/11/06 06:00
MHDA- 2015/05/12 06:00
CRDT- 2013/11/06 06:00
PHST- 2013/06/25 00:00 [received]
PHST- 2013/08/28 00:00 [revised]
PHST- 2013/09/01 00:00 [accepted]
PHST- 2013/11/06 06:00 [entrez]
PHST- 2013/11/06 06:00 [pubmed]
PHST- 2015/05/12 06:00 [medline]
AID - S0167-8140(13)00522-7 [pii]
AID - 10.1016/j.radonc.2013.09.027 [doi]
PST - ppublish
SO  - Radiother Oncol. 2014 Mar;110(3):441-7. doi: 10.1016/j.radonc.2013.09.027. Epub 
      2013 Nov 1.