PMID- 24189016
OWN - NLM
STAT- MEDLINE
DCOM- 20140127
LR  - 20161128
IS  - 1535-3699 (Electronic)
IS  - 1535-3699 (Linking)
VI  - 238
IP  - 12
DP  - 2013 Dec
TI  - Normobaric, intermittent hypoxia conditioning is cardio- and vasoprotective in 
      rats.
PG  - 1413-20
LID - 10.1177/1535370213508718 [doi]
AB  - Favorable versus detrimental cardiovascular responses to intermittent hypoxia 
      conditioning (IHC) are heavily dependent on experimental or pathological 
      conditions, including the duration, frequency and intensity of the hypoxia 
      exposures. Recently, we demonstrated that a program of moderate, normobaric IHC 
      (FIO2 9.5-10% for 5-10 min/cycle, with intervening 4 min normoxia, 5-8 cycles/day 
      for 20 days) in dogs afforded robust cardioprotection against infarction and 
      arrhythmias induced by coronary artery occlusion-reperfusion, but this protection 
      has not been verified in other species. Accordingly, in this investigation 
      cardio- as well as vasoprotection were examined in male Wistar rats completing 
      the normobaric IHC program or a sham program in which the rats continuously 
      breathed atmospheric air. Myocardial ischemia and reperfusion (IR) was imposed by 
      occlusion and reperfusion of the left anterior descending coronary artery in in 
      situ experiments and by subjecting isolated, perfused hearts to global 
      ischemia-reperfusion. Cardiac arrhythmias and myocardial infarct size were 
      quantified in in situ experiments. Endothelial function was evaluated from the 
      relaxation to acetylcholine of norepinephrine-precontracted aortic rings taken 
      from in situ IR experiments, and from the increase in coronary flow produced by 
      acetylcholine in isolated hearts. IHC sharply reduced cardiac arrhythmias during 
      ischemia and decreased infarct size by 43% following IR. Endothelial dysfunction 
      in aorta was marked after IR in sham rats, but not significant in IHC rats. 
      Similar findings were found for the coronary circulations of isolated hearts. 
      These findings support the hypothesis that moderate, normobaric IHC is cardio- 
      and vasoprotective in a rat model of IR.
FAU - Manukhina, Eugenia B
AU  - Manukhina EB
AD  - Laboratory of Adaptation, Institute for General Pathology and Pathophysiology, 
      Moscow 125315, Russian Federation.
FAU - Belkina, Ludmila M
AU  - Belkina LM
FAU - Terekhina, Olga L
AU  - Terekhina OL
FAU - Abramochkin, Denis V
AU  - Abramochkin DV
FAU - Smirnova, Elena A
AU  - Smirnova EA
FAU - Budanova, Olga P
AU  - Budanova OP
FAU - Mallet, Robert T
AU  - Mallet RT
FAU - Downey, H Fred
AU  - Downey HF
LA  - eng
GR  - R01NS076975/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20131104
PL  - Switzerland
TA  - Exp Biol Med (Maywood)
JT  - Experimental biology and medicine (Maywood, N.J.)
JID - 100973463
SB  - IM
MH  - Animals
MH  - Aorta/physiology/physiopathology
MH  - Arrhythmias, Cardiac/physiopathology/prevention & control
MH  - *Cardiovascular Physiological Phenomena
MH  - Cardiovascular System/physiopathology
MH  - Endothelium, Vascular/physiology/physiopathology
MH  - Hypoxia/*physiopathology
MH  - Ischemic Preconditioning, Myocardial/*methods
MH  - Male
MH  - Myocardial Ischemia/physiopathology/prevention & control
MH  - Myocardial Reperfusion
MH  - Myocardial Reperfusion Injury/physiopathology/prevention & control
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - Acetylcholine
OT  - aorta
OT  - coronary circulation
OT  - myocardial infarction
OT  - myocardial ischemia and reperfusion
OT  - nitric oxide
EDAT- 2013/11/06 06:00
MHDA- 2014/01/28 06:00
CRDT- 2013/11/06 06:00
PHST- 2013/11/06 06:00 [entrez]
PHST- 2013/11/06 06:00 [pubmed]
PHST- 2014/01/28 06:00 [medline]
AID - 1535370213508718 [pii]
AID - 10.1177/1535370213508718 [doi]
PST - ppublish
SO  - Exp Biol Med (Maywood). 2013 Dec;238(12):1413-20. doi: 10.1177/1535370213508718. 
      Epub 2013 Nov 4.