PMID- 24189124
OWN - NLM
STAT- MEDLINE
DCOM- 20150416
LR  - 20140417
IS  - 1753-4267 (Electronic)
IS  - 1753-4259 (Linking)
VI  - 20
IP  - 4
DP  - 2014 May
TI  - Myeloperoxidase influences the complement regulatory function of modified 
      C-reactive protein.
PG  - 440-8
LID - 10.1177/1753425913508164 [doi]
AB  - In patients with active anti-neutrophil cytoplasmic Ab (ANCA)-associated 
      vasculitis (AAV), there are high levels of circulating C-reactive protein (CRP), 
      which can inhibit the alternative complement pathway by binding factor H and 
      triggering the classical complement pathway by binding C1q. However, the 
      alternative, not the classical, complement pathway has been proven to play an 
      important role in AAV. We found that both purified myeloperoxidase (MPO) and MPO 
      released from ANCA-stimulated neutrophils could bind modified CRP (mCRP), but not 
      pentameric CRP. Furthermore, MPO could block the binding between mCRP and factor 
      H, as well as the binding between mCRP and C1q. Binding with mCRP did not 
      influence the enzymatic activity of MPO. Binding with mCRP also did not influence 
      the binding between MPO and its physical inhibitor, ceruloplasmin, as well as the 
      binding between MPO and MPO-ANCA. The results indicated that MPO might be a 
      complement regulator and inhibit the negative regulatory effect of CRP on the 
      alternative complement pathway.
FAU - Xu, Peng-cheng
AU  - Xu PC
AD  - 1Renal Division, Department of Medicine, Peking University First Hospital, 
      Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, 
      Ministry of Health of China, Peking-Tsinghua Center for Life Sciences, Beijing, 
      PR China.
FAU - Li, Zhi-ying
AU  - Li ZY
FAU - Yang, Xiao-wei
AU  - Yang XW
FAU - Zhao, Ming-hui
AU  - Zhao MH
FAU - Chen, Min
AU  - Chen M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131104
PL  - United States
TA  - Innate Immun
JT  - Innate immunity
JID - 101469670
RN  - 80295-33-6 (Complement C1q)
RN  - 80295-65-4 (Complement Factor H)
RN  - 9007-36-7 (Complement System Proteins)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 1.11.1.7 (Peroxidase)
RN  - EC 1.16.3.1 (Ceruloplasmin)
SB  - IM
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
MH  - C-Reactive Protein/*immunology
MH  - Ceruloplasmin/pharmacology
MH  - Complement C1q/metabolism
MH  - Complement Factor H/metabolism
MH  - Complement Pathway, Alternative
MH  - Complement Pathway, Classical
MH  - Complement System Proteins/metabolism
MH  - Humans
MH  - Immunomodulation
MH  - Neutrophils/*immunology
MH  - Peroxidase/*metabolism
MH  - Protein Binding
OTO - NOTNLM
OT  - C-reactive protein
OT  - Myeloperoxidase
OT  - anti-neutrophil cytoplasmic Ab
OT  - complement
OT  - vasculitis
EDAT- 2013/11/06 06:00
MHDA- 2015/04/17 06:00
CRDT- 2013/11/06 06:00
PHST- 2013/11/06 06:00 [entrez]
PHST- 2013/11/06 06:00 [pubmed]
PHST- 2015/04/17 06:00 [medline]
AID - 1753425913508164 [pii]
AID - 10.1177/1753425913508164 [doi]
PST - ppublish
SO  - Innate Immun. 2014 May;20(4):440-8. doi: 10.1177/1753425913508164. Epub 2013 Nov 
      4.