PMID- 2418961
OWN - NLM
STAT- MEDLINE
DCOM- 19860423
LR  - 20071114
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 46
IP  - 4 Pt 2
DP  - 1986 Apr
TI  - Mammary tumorigenesis and tumor morphology in four C3H sublines with or without 
      exogenous mammary tumor virus.
PG  - 2096-100
AB  - Mammary tumorigenesis was surveyed in retired breeding females in four sublines 
      of the C3H strain: in standard milk-transmitted early oncogenic mouse mammary 
      tumor virus (MMTV)-infected C3H/He and C3H/Ki mice, and in standard 
      milk-transmitted early oncogenic MMTV free C3Hf/He and C3Hf/Ki mice. All of 58 
      C3H/Ki mice and 98% (306 of 309) of the C3H/He mice developed palpable mammary 
      tumors at average ages of 276 and 284 days, respectively. Thirty-one % (47 of 
      152) of the C3Hf/Ki mice and 77% (168 of 218) of the C3Hf/He mice developed 
      palpable mammary tumors at average ages of 798 and 757 days, respectively. The 
      mammary tumors removed from C3H/He and C3H/Ki mice were all adenocarcinomas of 
      epithelial origin, and all contained MMTV. The mammary tumors removed from 
      C3Hf/He and C3Hf/Ki mice were either adenocarcinomas or sarcomas. The carcinomas 
      were of epithelial origin and all expressed the late oncogenic endogenous MMTV. 
      The sarcomas were of histiocyte or fibrocyte origin and contained neither virus 
      particles nor MMTV antigenic markers. It is concluded that exogenous standard 
      milk-transmitted oncogenic MMTV oncogenesis in C3H mice is not modified by host 
      genetic factors. In contrast, late oncogenic endogenous MMTV oncogenesis is 
      influenced both by host genetic control of the expression of the late oncogenic 
      MMTV provirus and by the location of the proviral genes in the germline DNA.
FAU - Vaage, J
AU  - Vaage J
FAU - Smith, G H
AU  - Smith GH
FAU - Asch, B B
AU  - Asch BB
FAU - Teramoto, Y
AU  - Teramoto Y
LA  - eng
GR  - CA-29660/CA/NCI NIH HHS/United States
GR  - CA-32937/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (Vimentin)
RN  - 68238-35-7 (Keratins)
SB  - IM
MH  - Adenocarcinoma/etiology/pathology
MH  - Animals
MH  - Disease Models, Animal
MH  - Female
MH  - Genes, Viral
MH  - Keratins/analysis
MH  - Mammary Neoplasms, Experimental/*etiology/pathology
MH  - Mammary Tumor Virus, Mouse/genetics/*isolation & purification
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Sarcoma/etiology/pathology
MH  - Vimentin/analysis
EDAT- 1986/04/01 00:00
MHDA- 1986/04/01 00:01
CRDT- 1986/04/01 00:00
PHST- 1986/04/01 00:00 [pubmed]
PHST- 1986/04/01 00:01 [medline]
PHST- 1986/04/01 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 1986 Apr;46(4 Pt 2):2096-100.