PMID- 24190238
OWN - NLM
STAT- MEDLINE
DCOM- 20140609
LR  - 20191112
IS  - 1880-313X (Electronic)
IS  - 0388-6107 (Linking)
VI  - 34
IP  - 5
DP  - 2013
TI  - Anxiolytic-like effect of trans-2-decenoic acid ethyl ester in stress-induced 
      anxiety-like model mice.
PG  - 259-67
AB  - Brain-derived neurotrophic factor (BDNF) is considered to be involved in the 
      etiology and treatment of stress-related mood disorders including anxiety. 
      However, application of BDNF itself has many technical and pharmacological 
      problems such as instability and/or a lack of appropriate delivery systems. To 
      overcome these, we developed trans-2-decenoic acid ethyl ester (DAEE) as a stable 
      and small molecule with BDNF-like activities. In the present study, we tested the 
      activities of DAEE on a stress-induced anxiety-like mouse model. Mice were kept 
      in cages and subjected to 3 sets of sequential leaning, drenching, and rotation 
      as chronic mild stresses applied for 1-2 days over a 3-week period; and the 
      anxiety-like symptom (reduced time spent in open arm of the maze) was evaluated 
      by use of the elevated plus-maze test. A daily intraperitoneal administration of 
      DAEE competed against the expression of the anxiety-like symptom when 
      administered during the stress-loading period, and became therapeutic when 
      administered after the stress-loading. This activity was accompanied by 
      amelioration of the stress-induced reduction in the levels of BDNF and 
      neurotrophin-3 mRNAs and phosphorylated extracellular signal-regulated kinases 
      (ERK) 1/2 in the hippocampus. These results demonstrated that DAEE behaved like 
      an anxiolytic and ameliorated this characteristic anxiety-like symptom, 
      suggesting that DAEE may be a promising candidate for a novel anxiolytic with a 
      new mechanism of action.
FAU - Makino, Akihisa
AU  - Makino A
AD  - Laboratory of Molecular Biology, Department of Biofunctional Analysis, Gifu 
      Pharmaceutical University, Daigaku-nishi 1-25-4, Gifu 501-1196, Japan.
FAU - Iinuma, Munekazu
AU  - Iinuma M
FAU - Fukumitsu, Hidefumi
AU  - Fukumitsu H
FAU - Soumiya, Hitomi
AU  - Soumiya H
FAU - Furukawa, Yoshiko
AU  - Furukawa Y
FAU - Furukawa, Shoei
AU  - Furukawa S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Biomed Res
JT  - Biomedical research (Tokyo, Japan)
JID - 8100317
RN  - 0 (Fatty Acids, Monounsaturated)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (RNA, Messenger)
RN  - 332T8TH7B1 (2-decenoic acid)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
SB  - IM
MH  - Animals
MH  - Anxiety/drug therapy/*etiology
MH  - Disease Models, Animal
MH  - Fatty Acids, Monounsaturated/administration & dosage/chemistry/*pharmacology
MH  - Gene Expression Regulation/drug effects
MH  - Hippocampus/drug effects/metabolism
MH  - Male
MH  - Mice
MH  - Mitogen-Activated Protein Kinase 1/metabolism
MH  - Mitogen-Activated Protein Kinase 3/metabolism
MH  - Nerve Growth Factors/genetics/metabolism
MH  - Phosphorylation/drug effects
MH  - RNA, Messenger/genetics/metabolism
MH  - *Stress, Physiological
MH  - *Stress, Psychological
EDAT- 2013/11/06 06:00
MHDA- 2014/06/10 06:00
CRDT- 2013/11/06 06:00
PHST- 2013/11/06 06:00 [entrez]
PHST- 2013/11/06 06:00 [pubmed]
PHST- 2014/06/10 06:00 [medline]
AID - DN/JST.JSTAGE/biomedres/34.259 [pii]
AID - 10.2220/biomedres.34.259 [doi]
PST - ppublish
SO  - Biomed Res. 2013;34(5):259-67. doi: 10.2220/biomedres.34.259.