PMID- 24191918
OWN - NLM
STAT- MEDLINE
DCOM- 20140903
LR  - 20140120
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
VI  - 39
IP  - 2
DP  - 2014 Jan
TI  - Fish oil improves anxiety-like, depressive-like and cognitive behaviors in 
      olfactory bulbectomised rats.
PG  - 266-74
LID - 10.1111/ejn.12406 [doi]
AB  - Depression is increasingly present in the population, and its pathophysiology and 
      treatment have been investigated with several animal models, including olfactory 
      bulbectomy (Obx). Fish oil (FO) supplementation during the prenatal and postnatal 
      periods decreases depression-like and anxiety-like behaviors. The present study 
      evaluated the effect of FO supplementation on Obx-induced depressive-like 
      behavior and cognitive impairment. Female rats received supplementation with FO 
      during habituation, mating, gestation, and lactation, and their pups were 
      subjected to Obx in adulthood; after the recovery period, the adult offspring 
      were subjected to behavioral tests, and the hippocampal levels of brain-derived 
      neurotrophic factor (BDNF), serotonin (5-HT) and the metabolite 
      5-hydroxyindoleacetic (5-HIAA) were determined. Obx led to increased anxiety-like 
      and depressive-like behaviors, and impairment in the object location task. All 
      behavioral changes were reversed by FO supplementation. Obx caused reductions in 
      the levels of hippocampal BDNF and 5-HT, whereas FO supplementation restored 
      these levels to normal values. In control rats, FO increased the hippocampal 
      level of 5-HT and reduced that of 5-HIAA, indicating low 5-HT metabolism in this 
      brain region. The present results indicate that FO supplementation during 
      critical periods of brain development attenuated anxiety-like and depressive-like 
      behaviors and cognitive dysfunction induced by Obx. These results may be 
      explained by increased levels of hippocampal BDNF and 5-HT, two major regulators 
      of neuronal survival and long-term plasticity in this brain structure.
CI  - (c) 2013 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
FAU - Pudell, Claudia
AU  - Pudell C
AD  - Laboratorio de Neurofisiologia, Departamento de Fisiologia, Universidade Federal 
      do Parana, 81.531-990, Curitiba, PR, Brazil.
FAU - Vicente, Bianca A
AU  - Vicente BA
FAU - Delattre, Ana M
AU  - Delattre AM
FAU - Carabelli, Bruno
AU  - Carabelli B
FAU - Mori, Marco A
AU  - Mori MA
FAU - Suchecki, Deborah
AU  - Suchecki D
FAU - Machado, Ricardo B
AU  - Machado RB
FAU - Zanata, Silvio M
AU  - Zanata SM
FAU - Visentainer, Jesui V
AU  - Visentainer JV
FAU - de Oliveira Santos Junior, Oscar
AU  - de Oliveira Santos Junior O
FAU - Lima, Marcelo M S
AU  - Lima MM
FAU - Ferraz, Anete C
AU  - Ferraz AC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131106
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Central Nervous System Agents)
RN  - 0 (Fish Oils)
RN  - 333DO1RDJY (Serotonin)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
SB  - IM
MH  - Animals
MH  - Anxiety Disorders/*drug therapy/metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Central Nervous System Agents/*therapeutic use
MH  - Cognition Disorders/*drug therapy/metabolism
MH  - Depressive Disorder/*drug therapy/metabolism
MH  - Female
MH  - Fish Oils/*therapeutic use
MH  - Hippocampus/drug effects/growth & development/metabolism
MH  - Hydroxyindoleacetic Acid/metabolism
MH  - Male
MH  - Neuropsychological Tests
MH  - Olfactory Bulb/physiology/surgery
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Wistar
MH  - Serotonin/metabolism
OTO - NOTNLM
OT  - BDNF
OT  - depression
OT  - memory
OT  - serotonin
OT  - omega-3 polyunsaturated fatty acids
EDAT- 2013/11/07 06:00
MHDA- 2014/09/04 06:00
CRDT- 2013/11/07 06:00
PHST- 2013/06/14 00:00 [received]
PHST- 2013/10/01 00:00 [revised]
PHST- 2013/10/03 00:00 [accepted]
PHST- 2013/11/07 06:00 [entrez]
PHST- 2013/11/07 06:00 [pubmed]
PHST- 2014/09/04 06:00 [medline]
AID - 10.1111/ejn.12406 [doi]
PST - ppublish
SO  - Eur J Neurosci. 2014 Jan;39(2):266-74. doi: 10.1111/ejn.12406. Epub 2013 Nov 6.