PMID- 24196454
OWN - NLM
STAT- MEDLINE
DCOM- 20140925
LR  - 20211021
IS  - 1863-2300 (Electronic)
IS  - 1863-2297 (Print)
IS  - 1863-2297 (Linking)
VI  - 36
IP  - 1
DP  - 2014 Jan
TI  - Dendritic cells in atherosclerosis.
PG  - 93-102
LID - 10.1007/s00281-013-0400-x [doi]
AB  - Atherosclerosis is a chronic inflammatory disease with activation of both the 
      innate and adaptive arms of the immune system. Dendritic cells (DCs) are potent 
      activators of adaptive immunity and have been identified in the normal arterial 
      wall and within atherosclerotic lesions. Recent evidence points to a functional 
      role for DCs in all stages of atherosclerosis because of their myriad functions 
      including lipid uptake, antigen presentation, efferocytosis, and inflammation 
      resolution. Moreover, DC-based vaccination strategies are currently being 
      developed for the treatment of atherosclerosis. This review will focus on the 
      current evidence as well as the proposed roles for DCs in the pathogenesis of 
      atherosclerosis and discuss future therapeutic strategies.
FAU - Subramanian, Manikandan
AU  - Subramanian M
AD  - Department of Medicine, Columbia University, 630 West 168th Street PH9-406, New 
      York, NY, 10032, USA, ms4144@columbia.edu.
FAU - Tabas, Ira
AU  - Tabas I
LA  - eng
GR  - R01 HL107497/HL/NHLBI NIH HHS/United States
GR  - P01 HL054591/HL/NHLBI NIH HHS/United States
GR  - HL054591/HL/NHLBI NIH HHS/United States
GR  - R01 HL081181/HL/NHLBI NIH HHS/United States
GR  - R01 HL075662/HL/NHLBI NIH HHS/United States
GR  - HL075662/HL/NHLBI NIH HHS/United States
GR  - HL106019/HL/NHLBI NIH HHS/United States
GR  - R01 HL106019/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20131106
PL  - Germany
TA  - Semin Immunopathol
JT  - Seminars in immunopathology
JID - 101308769
SB  - IM
MH  - Animals
MH  - Atherosclerosis/*immunology
MH  - Blood Vessels/cytology/immunology/metabolism
MH  - Dendritic Cells/*immunology/metabolism
MH  - Humans
PMC - PMC3946524
MID - NIHMS539100
EDAT- 2013/11/08 06:00
MHDA- 2014/09/26 06:00
PMCR- 2014/07/01
CRDT- 2013/11/08 06:00
PHST- 2013/06/10 00:00 [received]
PHST- 2013/10/13 00:00 [accepted]
PHST- 2013/11/08 06:00 [entrez]
PHST- 2013/11/08 06:00 [pubmed]
PHST- 2014/09/26 06:00 [medline]
PHST- 2014/07/01 00:00 [pmc-release]
AID - 10.1007/s00281-013-0400-x [doi]
PST - ppublish
SO  - Semin Immunopathol. 2014 Jan;36(1):93-102. doi: 10.1007/s00281-013-0400-x. Epub 
      2013 Nov 6.