PMID- 24196800
OWN - NLM
STAT- MEDLINE
DCOM- 20131203
LR  - 20131107
IS  - 1556-8539 (Print)
IS  - 1556-8539 (Linking)
VI  - 7
IP  - 4
DP  - 2012
TI  - Enhancement of cancer stem cell susceptibility to conventional treatments through 
      complementary yoga therapy: possible cellular and molecular mechanisms.
PG  - 261-7
LID - jsc.2013.7.4.261 [pii]
AB  - Cancer stem cells (CSCs) are stem-like tumor populations that are reported to 
      contribute towards tumor growth, maintenance and recurrence after therapy. 
      Hypoxia increases CSC fraction and promotes acquisition of a stem-cell-like 
      state. Cancer stem cells are critically dependant on the hypoxia-inducible 
      factor-1 (HIF-1) for survival, self-renewal, tumor growth and maintenance of 
      their undifferentiated phenotype. Recent researches show that stage of 
      differentiation of the tumor cells is predictive of their susceptibility to 
      natural killer cell (NK) cell mediated cytotoxicity and cancer stem cells are 
      significant targets of NK cell cytotoxicity. Studies also show that reversion of 
      tumor cells to a less-differentiated phenotype can be achieved by blocking NFkappaB. 
      Yoga therapy (yogic lifestyle modifications encompassing physical postures, 
      breathing practices, relaxation techniques and meditations) is known to modulate 
      neural, endocrine and immune functions at the cellular level through influencing 
      cell cycle control, aging, oxidative stress, apoptosis and several pathways of 
      stress signaling molecules. Yoga therapy has also been shown to enhance natural 
      killer cell activity and modulate stress and DNA damage in breast cancer patients 
      receiving radiotherapy. Recent study found that brief daily yogic meditation may 
      reverse the pattern of increased NFkappaB-related transcription of pro-inflammatory 
      cytokines in leukocytes. Thus, yoga therapy has the potential to reduce cancer 
      stem cell survival, self -renewal and tumor growth by modifying the tumor 
      micro-environment through various mechanisms such as; 1) reducing HIF-1 activity 
      by enhanced oxygenation, 2) promoting NK cell activity directly (or indirectly 
      through down regulating NFkappaB expression), thereby enhancing NK cell mediated CSC 
      lysis, and 3) by minimizing the aberrant expressions or activities of various 
      hormones, cytokines, chemokines and tumor signaling pathways. Yoga therapy may 
      have a synergistic effect with conventional modalities of treatment in preventing 
      cancer progression and recurrences.
FAU - Bhargav, Hemant
AU  - Bhargav H
FAU - Metri, Kashinath
AU  - Metri K
FAU - Raghuram, Nagarathna
AU  - Raghuram N
FAU - Ramarao, Nagendra Hongasandra
AU  - Ramarao NH
FAU - Koka, Prasad S
AU  - Koka PS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Stem Cells
JT  - Journal of stem cells
JID - 101295936
SB  - IM
MH  - Cell Hypoxia
MH  - Combined Modality Therapy
MH  - Humans
MH  - Neoplasms/immunology/metabolism/pathology/*therapy
MH  - Neoplastic Stem Cells/immunology/metabolism/*pathology
MH  - Signal Transduction
MH  - Treatment Outcome
MH  - Tumor Microenvironment
MH  - *Yoga
EDAT- 2012/01/01 00:00
MHDA- 2013/12/16 06:00
CRDT- 2013/11/08 06:00
PHST- 2013/11/08 06:00 [entrez]
PHST- 2012/01/01 00:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - jsc.2013.7.4.261 [pii]
PST - ppublish
SO  - J Stem Cells. 2012;7(4):261-7.