PMID- 2419700
OWN - NLM
STAT- MEDLINE
DCOM- 19860331
LR  - 20190724
IS  - 0160-2446 (Print)
IS  - 0160-2446 (Linking)
VI  - 8
IP  - 1
DP  - 1986 Jan-Feb
TI  - Protection by the calcium antagonist tiapamil, against cardiac lymphatic enzyme 
      leakage and arrhythmias in canine hearts during reperfusion.
PG  - 90-8
AB  - We examined the effects of tiapamil, a Ca2+ antagonist, on infarct size, 
      lymphatic enzyme release, and arrhythmias in reperfused, ischemic canine hearts. 
      Three-hour reperfusion of the left anterior descending coronary artery, which had 
      been ligated for 3 h, significantly increased cardiac lymphatic release of 
      lactate dehydrogenase (LDH), cathepsin D and creatine phosphokinase (CPK), and 
      the incidence of ventricular premature contractions (VPCs), the increases being 
      markedly higher than those in ligation period. Tiapamil, at the i.v. dose of 3 
      mg/kg/h for 6 h during the ligation and reperfusion periods markedly reduced 
      these increases in lymphatic levels of LDH and cathepsin D and in VPCs, and 
      significantly decreased infarct size. Tiapamil treatment only during the ligation 
      period had similar preserving effects, but tiapamil treatment only during 
      reperfusion did not. These results suggest that blockade of the Ca2+ channel must 
      be achieved during the early phase of an ischemic episode in order to prevent 
      myocardial deterioration during reperfusion.
FAU - Matsuura, A
AU  - Matsuura A
FAU - Ishihara, T
AU  - Ishihara T
FAU - Nakamura, K
AU  - Nakamura K
FAU - Himori, N
AU  - Himori N
FAU - Nakamura, K
AU  - Nakamura K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Cardiovasc Pharmacol
JT  - Journal of cardiovascular pharmacology
JID - 7902492
RN  - 0 (Calcium Channel Blockers)
RN  - 0 (Propylamines)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
RN  - EC 2.7.3.2 (Creatine Kinase)
RN  - EC 3.4.23.5 (Cathepsin D)
RN  - V824N2T753 (Tiapamil Hydrochloride)
SB  - IM
MH  - Animals
MH  - Arrhythmias, Cardiac/etiology/*prevention & control
MH  - Calcium Channel Blockers/pharmacology
MH  - Cathepsin D/metabolism
MH  - Coronary Disease/*drug therapy/physiopathology
MH  - Creatine Kinase/metabolism
MH  - Dogs
MH  - Female
MH  - L-Lactate Dehydrogenase/metabolism
MH  - Lymphatic System/drug effects/enzymology
MH  - Male
MH  - Myocardial Infarction/drug therapy/pathology/physiopathology
MH  - Propylamines/administration & dosage/*pharmacology
MH  - Tiapamil Hydrochloride
MH  - Time Factors
EDAT- 1986/01/01 00:00
MHDA- 1986/01/01 00:01
CRDT- 1986/01/01 00:00
PHST- 1986/01/01 00:00 [pubmed]
PHST- 1986/01/01 00:01 [medline]
PHST- 1986/01/01 00:00 [entrez]
AID - 10.1097/00005344-198601000-00015 [doi]
PST - ppublish
SO  - J Cardiovasc Pharmacol. 1986 Jan-Feb;8(1):90-8. doi: 
      10.1097/00005344-198601000-00015.