PMID- 24198753
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140218
LR  - 20211021
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 7
DP  - 2013 Oct 30
TI  - Toward a unified biological hypothesis for the BDNF Val66Met-associated memory 
      deficits in humans: a model of impaired dendritic mRNA trafficking.
PG  - 188
LID - 10.3389/fnins.2013.00188 [doi]
LID - 188
AB  - Brain-derived neurotrophic factor (BDNF) represents promotesa key molecule for 
      the survival and differentiation of specific populations of neurons in the 
      central nervous system. BDNF also regulates plasticity-related processes 
      underlying memory and learning. A common single nucleotide polymorphism (SNP) 
      rs6265 has been identified on the coding sequence of human BDNF located at 11p13. 
      The SNP rs6265 is a single base mutation with an adenine instead of a guanine at 
      position 196 (G196A), resulting in the amino acid substitution Val66Met. This 
      polymorphism only exists in humans and has been associated with a plethora of 
      effects ranging from molecular, cellular and brain structural modifications in 
      association with deficits in social and cognitive functions. To date, the 
      literature on Val66Met polymorphism describes a complex and often conflicting 
      pattern of effects. In this review, we attempt to provide a unifying model of the 
      Val66Met effects. We discuss the clinical evidence of the association between 
      Val66Met and memory deficits, as well as the molecular mechanisms involved 
      including the reduced transport of BDNF mRNA to the dendrites as well as the 
      reduced processing and secretion of BDNF protein through the regulated secretory 
      pathway.
FAU - Baj, Gabriele
AU  - Baj G
AD  - Department of Life Sciences, Brain Centre for Neurosciences, University of 
      Trieste Trieste, Italy.
FAU - Carlino, Davide
AU  - Carlino D
FAU - Gardossi, Lucia
AU  - Gardossi L
FAU - Tongiorgi, Enrico
AU  - Tongiorgi E
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20131030
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC3812868
OTO - NOTNLM
OT  - BDNF
OT  - dendritic mRNA trafficking
OT  - hippocampus atrophy
OT  - memory deficits
OT  - neurotrophins
OT  - post-traumatic stress disorder
OT  - regulated protein secretion
EDAT- 2013/11/08 06:00
MHDA- 2013/11/08 06:01
PMCR- 2013/01/01
CRDT- 2013/11/08 06:00
PHST- 2013/07/25 00:00 [received]
PHST- 2013/09/29 00:00 [accepted]
PHST- 2013/11/08 06:00 [entrez]
PHST- 2013/11/08 06:00 [pubmed]
PHST- 2013/11/08 06:01 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2013.00188 [doi]
PST - epublish
SO  - Front Neurosci. 2013 Oct 30;7:188. doi: 10.3389/fnins.2013.00188.