PMID- 24199166
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131107
LR  - 20211021
IS  - 2233-6079 (Print)
IS  - 2233-6087 (Electronic)
IS  - 2233-6079 (Linking)
VI  - 37
IP  - 5
DP  - 2013 Oct
TI  - Risk factors for the progression of intima-media thickness of carotid arteries: a 
      2-year follow-up study in patients with newly diagnosed type 2 diabetes.
PG  - 365-74
LID - 10.4093/dmj.2013.37.5.365 [doi]
AB  - BACKGROUND: Intima-media thickness (IMT) of the carotid arteries is known to have 
      a positive correlation with the risk of cardiovascular disease. This study was 
      designed to identify risk factors affecting the progression of carotid IMT in 
      patients with type 2 diabetes mellitus (T2DM). METHODS: Patients with newly 
      diagnosed T2DM with carotid IMT measurements were enrolled, and their clinical 
      data and carotid IMT results at baseline and 2 years later were compared. 
      RESULTS: Of the 171 patients, 67.2% of males and 50.8% of females had abnormal 
      baseline IMT of the left common carotid artery. At baseline, systolic blood 
      pressure, body mass index and smoking in male participants, and fasting plasma 
      glucose and glycated hemoglobin levels in females were significantly higher in 
      patients with abnormal IMT than in those with normal IMT. Low density lipoprotein 
      cholesterol (LDL-C) levels in males and high density lipoprotein cholesterol 
      (HDL-C) levels in females at the 2-year follow-up were significantly different 
      between the nonprogression and the progression groups. Reduction of the United 
      Kingdom Prospective Diabetes Study (UKPDS) 10-year coronary heart disease (CHD) 
      risk score after 2 years was generally higher in the nonprogression group than 
      the progression group. CONCLUSION: LDL-C levels in males and HDL-C levels in 
      females at the 2-year follow-up were significantly different between participants 
      with and without progression of carotid IMT. Furthermore, a reduction in the 
      UKPDS 10-year CHD risk score appeared to delay the advancement of 
      atherosclerosis. Therefore, the importance of establishing the therapeutic goal 
      of lipid profiles should be emphasized to prevent the progression of carotid IMT 
      in newly diagnosed T2DM patients.
FAU - Chin, Sang Ouk
AU  - Chin SO
AD  - Department of Endocrinology and Metabolism, Kyung Hee University School of 
      Medicine, Seoul, Korea.
FAU - Hwang, Jin Kyung
AU  - Hwang JK
FAU - Rhee, Sang Youl
AU  - Rhee SY
FAU - Chon, Suk
AU  - Chon S
FAU - Hwang, You-Cheol
AU  - Hwang YC
FAU - Oh, Seungjoon
AU  - Oh S
FAU - Ahn, Kyu Jeung
AU  - Ahn KJ
FAU - Chung, Ho Yeon
AU  - Chung HY
FAU - Woo, Jeong-Taek
AU  - Woo JT
FAU - Kim, Sung-Woon
AU  - Kim SW
FAU - Kim, Young Seol
AU  - Kim YS
FAU - Kang, Ja-Heon
AU  - Kang JH
FAU - Jeong, In-Kyung
AU  - Jeong IK
LA  - eng
PT  - Journal Article
DEP - 20131017
PL  - Korea (South)
TA  - Diabetes Metab J
JT  - Diabetes & metabolism journal
JID - 101556588
PMC - PMC3816138
OTO - NOTNLM
OT  - Atherosclerosis
OT  - Carotid artery intima-media thickness
OT  - Diabetes mellitus type 2
OT  - Risk factors
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2013/11/08 06:00
MHDA- 2013/11/08 06:01
PMCR- 2013/10/01
CRDT- 2013/11/08 06:00
PHST- 2013/02/13 00:00 [received]
PHST- 2013/05/07 00:00 [accepted]
PHST- 2013/11/08 06:00 [entrez]
PHST- 2013/11/08 06:00 [pubmed]
PHST- 2013/11/08 06:01 [medline]
PHST- 2013/10/01 00:00 [pmc-release]
AID - 10.4093/dmj.2013.37.5.365 [doi]
PST - ppublish
SO  - Diabetes Metab J. 2013 Oct;37(5):365-74. doi: 10.4093/dmj.2013.37.5.365. Epub 
      2013 Oct 17.