PMID- 2419975
OWN - NLM
STAT- MEDLINE
DCOM- 19860414
LR  - 20061115
IS  - 0036-7672 (Print)
IS  - 0036-7672 (Linking)
VI  - 116
IP  - 4
DP  - 1986 Jan 25
TI  - [Circulating interferon in patients with systemic lupus erythematosus. A 
      prospective study].
PG  - 104-9
AB  - The serum levels of interferon (IFN) were measured in 31 patients with systemic 
      lupus erythematosus (SLE). Among the 31 patients, 8 (25%) showed IFN in the sera: 
      in 4 patients IFN titers of 16 U/ml, and in the other 4 patients titers of 
      greater than or equal to 32 U/ml became detectable. Whereas antibodies to native 
      DNA (nDNA) were present in 6 of the 8 IFN positive patients, anti-nDNA antibodies 
      were only positive in 6 of the 23 IFN negative individuals (p less than 0.002). 
      Eight months after the first search for IFN in the patients' sera, 6 of the 8 IFN 
      positive patients showed reduced IFN serum levels and one each had an increased 
      or stable IFN titer. A good correlation between IFN titers and both the anti-nDNA 
      antibody titers and the disease activity was observed. However, there were 
      patients with active disease, high anti-nDNA titers but no IFN in the serum.
FAU - Dudli, C
AU  - Dudli C
FAU - Kaiser, V
AU  - Kaiser V
FAU - Aguet, M
AU  - Aguet M
FAU - Joller, H
AU  - Joller H
FAU - Pichler, W I
AU  - Pichler WI
FAU - Grob, P J
AU  - Grob PJ
FAU - Fontana, A
AU  - Fontana A
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Zirkulierendes Interferon bei Patienten mit systemischem Lupus erythematodes. 
      Eine prospektive Studie.
PL  - Switzerland
TA  - Schweiz Med Wochenschr
JT  - Schweizerische medizinische Wochenschrift
JID - 0404401
RN  - 0 (Antigen-Antibody Complex)
RN  - 0 (Autoantibodies)
RN  - 0 (Complement C3)
RN  - 0 (Complement C4)
RN  - 9007-49-2 (DNA)
RN  - 9008-11-1 (Interferons)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antigen-Antibody Complex/analysis
MH  - Autoantibodies/*analysis
MH  - Cells, Cultured
MH  - Child
MH  - Complement C3/analysis
MH  - Complement C4/analysis
MH  - DNA/*immunology
MH  - Female
MH  - Humans
MH  - Interferons/*analysis
MH  - Lupus Erythematosus, Systemic/*blood/immunology
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
EDAT- 1986/01/25 00:00
MHDA- 1986/01/25 00:01
CRDT- 1986/01/25 00:00
PHST- 1986/01/25 00:00 [pubmed]
PHST- 1986/01/25 00:01 [medline]
PHST- 1986/01/25 00:00 [entrez]
PST - ppublish
SO  - Schweiz Med Wochenschr. 1986 Jan 25;116(4):104-9.