PMID- 24200159
OWN - NLM
STAT- MEDLINE
DCOM- 20140627
LR  - 20131108
IS  - 1440-1827 (Electronic)
IS  - 1320-5463 (Linking)
VI  - 63
IP  - 9
DP  - 2013 Sep
TI  - Collision of extensive exocrine and neuroendocrine neoplasms in multiple 
      endocrine neoplasia type 1 revealed by cytogenetic analysis of loss of 
      heterozygosity: a case report.
PG  - 469-75
LID - 10.1111/pin.12088 [doi]
AB  - The combination of exocrine and neuroendocrine neoplasms is rarely found in the 
      pancreas. These combined lesions vary from a clonal tumor with mixed 
      differentiation to the incidental co-existence of two or more independent tumors, 
      but the differential diagnosis is sometimes difficult. Here we report a case of 
      multiple endocrine neoplasia type 1 (MEN1) with extensive ductal and 
      neuroendocrine neoplastic changes. These two types of tumors admixed markedly in 
      some parts, which made it difficult to determine the pathological diagnosis based 
      on histological findings. Cytogenetic analysis showed that loss of heterozygosity 
      (LOH) of the MEN1 locus exists in neuroendocrine but not in exocrine neoplasms, 
      indicating that independent mechanisms of tumorigenesis may occur in these two 
      types of tumors. This case shows the usefulness of cytogenetic analysis for the 
      diagnosis of combined tumors of the pancreas. Extensive exocrine neoplastic 
      change, including pancreatic intraepithelial neoplasia (PanIN) in virtually all 
      pancreatic ducts and a focus of intraductal papillary mucinous neoplasm (IPMN) 
      with focal invasion, was a distinguishing feature of the present case. The 
      possible association of ductal tumorigenesis and a MEN1 background is discussed.
CI  - (c) 2013 The Authors. Pathology International (c) 2013 Japanese Society of Pathology 
      and Wiley Publishing Asia Pty Ltd.
FAU - Moriyoshi, Koki
AU  - Moriyoshi K
AD  - Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.
FAU - Minamiguchi, Sachiko
AU  - Minamiguchi S
FAU - Miyagawa-Hayashino, Aya
AU  - Miyagawa-Hayashino A
FAU - Fujimoto, Masakazu
AU  - Fujimoto M
FAU - Kawaguchi, Michiya
AU  - Kawaguchi M
FAU - Haga, Hironori
AU  - Haga H
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20130828
PL  - Australia
TA  - Pathol Int
JT  - Pathology international
JID - 9431380
SB  - IM
MH  - Aged
MH  - Carcinoma in Situ/genetics/*pathology
MH  - Carcinoma, Neuroendocrine/genetics/*pathology
MH  - Cytogenetic Analysis/methods
MH  - Female
MH  - Humans
MH  - Loss of Heterozygosity/*genetics
MH  - Multiple Endocrine Neoplasia Type 1/genetics/*pathology
MH  - Mutation/genetics
MH  - Neoplasms, Multiple Primary/genetics/*pathology
MH  - Pancreas, Exocrine/pathology
MH  - Pancreatic Ducts/pathology
MH  - Pancreatic Neoplasms/genetics/*pathology
OTO - NOTNLM
OT  - loss of heterozygosity
OT  - multiple endocrine neoplasia type 1
OT  - neuroendocrine tumors
OT  - pancreatic ductal carcinoma
EDAT- 2013/11/10 06:00
MHDA- 2014/06/28 06:00
CRDT- 2013/11/09 06:00
PHST- 2013/05/07 00:00 [received]
PHST- 2013/07/18 00:00 [accepted]
PHST- 2013/11/09 06:00 [entrez]
PHST- 2013/11/10 06:00 [pubmed]
PHST- 2014/06/28 06:00 [medline]
AID - 10.1111/pin.12088 [doi]
PST - ppublish
SO  - Pathol Int. 2013 Sep;63(9):469-75. doi: 10.1111/pin.12088. Epub 2013 Aug 28.