PMID- 24201123
OWN - NLM
STAT- MEDLINE
DCOM- 20141224
LR  - 20230210
IS  - 1530-0285 (Electronic)
IS  - 0893-3952 (Linking)
VI  - 27
IP  - 5
DP  - 2014 May
TI  - Renal cell carcinoma with smooth muscle stroma lacks chromosome 3p and VHL 
      alterations.
PG  - 765-74
LID - 10.1038/modpathol.2013.180 [doi]
AB  - Renal cell carcinoma with prominent smooth muscle stroma is a rare neoplasm 
      composed of an admixture of epithelial cell with clear cytoplasm arranged in 
      small nest and tubular structures and a stroma composed of smooth muscle. In the 
      epithelial component, loss of chromosome 3p detected by fluorescence in situ 
      hybridization (FISH) has been reported and on this basis these neoplasms have 
      been viewed as variants of clear cell renal cell carcinoma. To test the validity 
      of this classification, we have evaluated the chromosome 3 and VHL status of 
      three of these tumors using FISH, array comparative genomic hybridization, gene 
      sequencing, and methylation-specific multiplex ligation-dependent probe 
      amplification analysis. None of the tumors showed deletion of chromosome 3p, VHL 
      mutation, a significant VHL methylation, or changes in VHL copy number and all 
      three tumors demonstrated a flat profile in the comparative genomic hybridization 
      analysis. We conclude that renal cell carcinoma with smooth muscle stroma should 
      be considered as an entity distinct from clear cell renal cell carcinoma.
FAU - Martignoni, Guido
AU  - Martignoni G
AD  - 1] Department of Pathology and Diagnostics, University of Verona, Verona, Italy 
      [2] Anatomia Patologica, Pederzoli Hospital, Peschiera, Verona, Italy.
FAU - Brunelli, Matteo
AU  - Brunelli M
AD  - Department of Pathology and Diagnostics, University of Verona, Verona, Italy.
FAU - Segala, Diego
AU  - Segala D
AD  - 1] Department of Pathology and Diagnostics, University of Verona, Verona, Italy 
      [2] Anatomia Patologica, Pederzoli Hospital, Peschiera, Verona, Italy.
FAU - Gobbo, Stefano
AU  - Gobbo S
AD  - 1] Department of Pathology and Diagnostics, University of Verona, Verona, Italy 
      [2] Anatomia Patologica, Pederzoli Hospital, Peschiera, Verona, Italy.
FAU - Borze, Ioana
AU  - Borze I
AD  - Department of Pathology, Hartmann Institute and HUSLab, University of Helsinki, 
      Helsinki, Finland.
FAU - Atanesyan, Lilit
AU  - Atanesyan L
AD  - MRC-Holland, Amsterdam, Netherlands.
FAU - Savola, Suvi
AU  - Savola S
AD  - MRC-Holland, Amsterdam, Netherlands.
FAU - Barzon, Luisa
AU  - Barzon L
AD  - Department of Histology, Microbiology and Medical Biotechnologies, University of 
      Padua, Padua, Italy.
FAU - Masi, Giulia
AU  - Masi G
AD  - Department of Histology, Microbiology and Medical Biotechnologies, University of 
      Padua, Padua, Italy.
FAU - Tardanico, Regina
AU  - Tardanico R
AD  - Department of Anatomic Pathology, Spedali Civili, Brescia, Italy.
FAU - Zhang, Shaobo
AU  - Zhang S
AD  - Department of Pathology and Laboratory Medicine, Indiana University School of 
      Medicine, Indianapolis, IN, USA.
FAU - Eble, John N
AU  - Eble JN
AD  - Department of Pathology and Laboratory Medicine, Indiana University School of 
      Medicine, Indianapolis, IN, USA.
FAU - Chilosi, Marco
AU  - Chilosi M
AD  - Department of Pathology and Diagnostics, University of Verona, Verona, Italy.
FAU - Bohling, Tom
AU  - Bohling T
AD  - Department of Pathology, Hartmann Institute and HUSLab, University of Helsinki, 
      Helsinki, Finland.
FAU - Cheng, Liang
AU  - Cheng L
AD  - Department of Pathology and Laboratory Medicine, Indiana University School of 
      Medicine, Indianapolis, IN, USA.
FAU - Delahunt, Brett
AU  - Delahunt B
AD  - Department of Pathology and Molecular Medicine, Wellington School of Medicine and 
      Health Sciences, University of Otago, Wellington, New Zealand.
FAU - Knuutila, Sakari
AU  - Knuutila S
AD  - Department of Pathology, Hartmann Institute and HUSLab, University of Helsinki, 
      Helsinki, Finland.
LA  - eng
PT  - Journal Article
DEP - 20131108
PL  - United States
TA  - Mod Pathol
JT  - Modern pathology : an official journal of the United States and Canadian Academy 
      of Pathology, Inc
JID - 8806605
RN  - EC 2.3.2.27 (Von Hippel-Lindau Tumor Suppressor Protein)
RN  - EC 6.3.2.- (VHL protein, human)
SB  - IM
MH  - Aged
MH  - Carcinoma, Renal Cell/*genetics/pathology
MH  - *Chromosomes, Human, Pair 3
MH  - Comparative Genomic Hybridization
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Kidney Neoplasms/*genetics/pathology
MH  - Muscle, Smooth/*pathology
MH  - Von Hippel-Lindau Tumor Suppressor Protein/*genetics
EDAT- 2013/11/10 06:00
MHDA- 2014/12/30 06:00
CRDT- 2013/11/09 06:00
PHST- 2013/01/15 00:00 [received]
PHST- 2013/06/17 00:00 [revised]
PHST- 2013/08/07 00:00 [accepted]
PHST- 2013/11/09 06:00 [entrez]
PHST- 2013/11/10 06:00 [pubmed]
PHST- 2014/12/30 06:00 [medline]
AID - S0893-3952(22)03591-8 [pii]
AID - 10.1038/modpathol.2013.180 [doi]
PST - ppublish
SO  - Mod Pathol. 2014 May;27(5):765-74. doi: 10.1038/modpathol.2013.180. Epub 2013 Nov 
      8.