PMID- 24201223
OWN - NLM
STAT- MEDLINE
DCOM- 20150413
LR  - 20140704
IS  - 1878-5832 (Electronic)
IS  - 1359-6446 (Linking)
VI  - 19
IP  - 7
DP  - 2014 Jul
TI  - A case study: semantic integration of gene-disease associations for type 2 
      diabetes mellitus from literature and biomedical data resources.
PG  - 882-9
LID - S1359-6446(13)00391-7 [pii]
LID - 10.1016/j.drudis.2013.10.024 [doi]
AB  - In the Semantic Enrichment of the Scientific Literature (SESL) project, 
      researchers from academia and from life science and publishing companies 
      collaborated in a pre-competitive way to integrate and share information for type 
      2 diabetes mellitus (T2DM) in adults. This case study exposes benefits from 
      semantic interoperability after integrating the scientific literature with 
      biomedical data resources, such as UniProt Knowledgebase (UniProtKB) and the Gene 
      Expression Atlas (GXA). We annotated scientific documents in a standardized way, 
      by applying public terminological resources for diseases and proteins, and other 
      text-mining approaches. Eventually, we compared the genetic causes of T2DM across 
      the data resources to demonstrate the benefits from the SESL triple store. Our 
      solution enables publishers to distribute their content with little overhead into 
      remote data infrastructures, such as into any Virtual Knowledge Broker.
CI  - Copyright (c) 2013. Published by Elsevier Ltd.
FAU - Rebholz-Schuhmann, Dietrich
AU  - Rebholz-Schuhmann D
AD  - European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, 
      Cambridge CB10 1SD, UK; Computerlinguistik, Universitat Zurich, Binzmuhlestrasse 
      14, 8050 Zurich, Switzerland. Electronic address: rebholz@ebi.ac.uk.
FAU - Grabmuller, Christoph
AU  - Grabmuller C
AD  - European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, 
      Cambridge CB10 1SD, UK.
FAU - Kavaliauskas, Silvestras
AU  - Kavaliauskas S
AD  - European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, 
      Cambridge CB10 1SD, UK.
FAU - Croset, Samuel
AU  - Croset S
AD  - European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, 
      Cambridge CB10 1SD, UK.
FAU - Woollard, Peter
AU  - Woollard P
AD  - GlaxoSmithKline, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, 
      Stevenage SG1 2NY, UK.
FAU - Backofen, Rolf
AU  - Backofen R
AD  - Albert-Ludwigs-University Freiburg, Fahnenbergplatz, D-79085 Freiburg, Germany.
FAU - Filsell, Wendy
AU  - Filsell W
AD  - Unilever R&D, Colworth Science Park, Sharnbrook MK44 1LQ, UK.
FAU - Clark, Dominic
AU  - Clark D
AD  - European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, 
      Cambridge CB10 1SD, UK.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20131104
PL  - England
TA  - Drug Discov Today
JT  - Drug discovery today
JID - 9604391
SB  - IM
MH  - Animals
MH  - Biomedical Research/*methods
MH  - Data Mining/*methods
MH  - Diabetes Mellitus, Type 2/diagnosis/*genetics
MH  - Humans
MH  - Knowledge Bases
MH  - *Semantics
MH  - *Systems Integration
EDAT- 2013/11/10 06:00
MHDA- 2015/04/14 06:00
CRDT- 2013/11/09 06:00
PHST- 2012/07/17 00:00 [received]
PHST- 2013/09/24 00:00 [revised]
PHST- 2013/10/28 00:00 [accepted]
PHST- 2013/11/09 06:00 [entrez]
PHST- 2013/11/10 06:00 [pubmed]
PHST- 2015/04/14 06:00 [medline]
AID - S1359-6446(13)00391-7 [pii]
AID - 10.1016/j.drudis.2013.10.024 [doi]
PST - ppublish
SO  - Drug Discov Today. 2014 Jul;19(7):882-9. doi: 10.1016/j.drudis.2013.10.024. Epub 
      2013 Nov 4.