PMID- 24201832
OWN - NLM
STAT- MEDLINE
DCOM- 20141013
LR  - 20211021
IS  - 1433-0431 (Electronic)
IS  - 0085-4530 (Linking)
VI  - 42
IP  - 12
DP  - 2013 Dec
TI  - [Biotechnological therapies for the treatment of back pain: alternatives to 
      corticosteroids].
PG  - 1054-61
LID - 10.1007/s00132-013-2197-7 [doi]
AB  - In recent years, it is increasingly clear that back pain is not only caused by 
      biomechanical problems. Currently, biologically-based local therapy concepts for 
      the treatment of affected spinal regions as an alternative to the standard 
      treatment with steroids are in development or in early stages of clinical 
      application. The common features of these new therapies are to intervene in the 
      regulation of homeostasis at various key points at the affected region and 
      specifically to suppress or block catabolic influences as well as to provide with 
      anti-inflammatory substances and growth factors. These include on one hand the 
      genetically produced Biologicals such as TNF-alpha inhibitors and cytokine 
      antagonists and on the other hand therapies with autologous blood preparations 
      (Autologous Conditioned Serum [ACS], and Platelet Rich Plasma formulations 
      [PRP]). This article presents the individual methods, gives an overview of 
      developments and results of various studies and discusses current 
      recommendations.
FAU - Moser, C
AU  - Moser C
AD  - Gronemeyer Institut fur Mikrotherapie; Lehrstuhl fur Radiologie und 
      Mikrotherapie, Universitat Witten/Herdecke, Universitatsstr. 142, 44799, Bochum, 
      Deutschland, moser@microtherapy.de.
FAU - Thiel, H-J
AU  - Thiel HJ
FAU - Gronemeyer, D
AU  - Gronemeyer D
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Retracted Publication
PT  - Review
TT  - Biotechnologische Konzepte zur Behandlung von Ruckenschmerzen : Erste Erfahrungen 
      mit Alternativen zu Glukokortikoiden.
PL  - Germany
TA  - Orthopade
JT  - Der Orthopade
JID - 0331266
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Biological Products)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
SB  - IM
RIN - Orthopade. 2014 Jul;43(7):688. PMID: 25100289
MH  - Adrenal Cortex Hormones/*therapeutic use
MH  - Anti-Inflammatory Agents/*therapeutic use
MH  - Antibodies, Monoclonal/*therapeutic use
MH  - Back Pain/*drug therapy
MH  - Biological Products/*therapeutic use
MH  - Blood Transfusion, Autologous/*methods
MH  - Drug Design
MH  - Evidence-Based Medicine
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/*therapeutic use
MH  - Treatment Outcome
EDAT- 2013/11/10 06:00
MHDA- 2014/10/14 06:00
CRDT- 2013/11/09 06:00
PHST- 2013/11/09 06:00 [entrez]
PHST- 2013/11/10 06:00 [pubmed]
PHST- 2014/10/14 06:00 [medline]
AID - 10.1007/s00132-013-2197-7 [doi]
PST - ppublish
SO  - Orthopade. 2013 Dec;42(12):1054-61. doi: 10.1007/s00132-013-2197-7.