PMID- 24205142
OWN - NLM
STAT- MEDLINE
DCOM- 20140918
LR  - 20220330
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 10
DP  - 2013
TI  - Effects of exercise intensity on spatial memory performance and hippocampal 
      synaptic plasticity in transient brain ischemic rats.
PG  - e78163
LID - 10.1371/journal.pone.0078163 [doi]
LID - e78163
AB  - Memory impairment is commonly noted in stroke survivors, and can lead to delay of 
      functional recovery. Exercise has been proved to improve memory in adult healthy 
      subjects. Such beneficial effects are often suggested to relate to hippocampal 
      synaptic plasticity, which is important for memory processing. Previous evidence 
      showed that in normal rats, low intensity exercise can improve synaptic 
      plasticity better than high intensity exercise. However, the effects of exercise 
      intensities on hippocampal synaptic plasticity and spatial memory after brain 
      ischemia remain unclear. In this study, we investigated such effects in brain 
      ischemic rats. The middle cerebral artery occlusion (MCAO) procedure was used to 
      induce brain ischemia. After the MCAO procedure, rats were randomly assigned to 
      sedentary (Sed), low-intensity exercise (Low-Ex), or high-intensity exercise 
      (High-Ex) group. Treadmill training began from the second day post MCAO 
      procedure, 30 min/day for 14 consecutive days for the exercise groups. The Low-Ex 
      group was trained at the speed of 8 m/min, while the High-Ex group at the speed 
      of 20 m/min. The spatial memory, hippocampal brain-derived neurotrophic factor 
      (BDNF), synapsin-I, postsynaptic density protein 95 (PSD-95), and dendritic 
      structures were examined to document the effects. Serum corticosterone level was 
      also quantified as stress marker. Our results showed the Low-Ex group, but not 
      the High-Ex group, demonstrated better spatial memory performance than the Sed 
      group. Dendritic complexity and the levels of BDNF and PSD-95 increased 
      significantly only in the Low-Ex group as compared with the Sed group in 
      bilateral hippocampus. Notably, increased level of corticosterone was found in 
      the High-Ex group, implicating higher stress response. In conclusion, after brain 
      ischemia, low intensity exercise may result in better synaptic plasticity and 
      spatial memory performance than high intensity exercise; therefore, the intensity 
      is suggested to be considered during exercise training.
FAU - Shih, Pei-Cheng
AU  - Shih PC
AD  - Department of Physical Therapy and Assistive Technology, National Yang-Ming 
      University, Taipei, Taiwan ; Department of Physical Therapy, Mackay Memorial 
      Hospital, Taipei, Taiwan.
FAU - Yang, Yea-Ru
AU  - Yang YR
FAU - Wang, Ray-Yau
AU  - Wang RY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131025
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Brain Ischemia/*metabolism/*physiopathology
MH  - Dendritic Spines/metabolism/physiology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Hippocampus/*cytology/*metabolism
MH  - Male
MH  - Memory/*physiology
MH  - Neuronal Plasticity/*physiology
MH  - *Physical Conditioning, Animal
MH  - Rats
MH  - Rats, Sprague-Dawley
PMC - PMC3808358
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/11/10 06:00
MHDA- 2014/09/19 06:00
PMCR- 2013/10/25
CRDT- 2013/11/09 06:00
PHST- 2013/07/05 00:00 [received]
PHST- 2013/09/17 00:00 [accepted]
PHST- 2013/11/09 06:00 [entrez]
PHST- 2013/11/10 06:00 [pubmed]
PHST- 2014/09/19 06:00 [medline]
PHST- 2013/10/25 00:00 [pmc-release]
AID - PONE-D-13-27844 [pii]
AID - 10.1371/journal.pone.0078163 [doi]
PST - epublish
SO  - PLoS One. 2013 Oct 25;8(10):e78163. doi: 10.1371/journal.pone.0078163. 
      eCollection 2013.