PMID- 24206741
OWN - NLM
STAT- MEDLINE
DCOM- 20141030
LR  - 20220317
IS  - 2090-2387 (Electronic)
IS  - 1687-1979 (Linking)
VI  - 14
IP  - 3
DP  - 2013 Sep
TI  - Efficacy of PPI, levofloxacin and amoxicillin in the eradication of Helicobacter 
      pylori compared to conventional triple therapy at a Venezuelan hospital.
PG  - 123-5
LID - S1687-1979(13)00127-5 [pii]
LID - 10.1016/j.ajg.2013.09.001 [doi]
AB  - BACKGROUND AND STUDY AIMS: Helicobacter pylori is the main cause of gastritis, 
      gastroduodenal ulcers and gastric cancer. In the past two decades, the 
      recommended treatment for its eradication as a first-line regimen is the standard 
      triple therapy consisting of a proton pump inhibitor (PPI), amoxicillin and 
      clarithromycin or metronidazole. However, the effectiveness of this traditional 
      regime, which initially was 90%, progressively declined in many parts of the 
      world and is currently 57-73%. The aim of this study was to evaluate whether the 
      eradication rate with triple therapy with levofloxacin is superior as first-line 
      therapy to that with treatment using clarithromycin in the population that 
      attended as outpatients at the Hospital of Lidice. PATIENTS AND METHODS: We 
      designed a prospective study, with two groups of patients presenting dyspeptic 
      symptoms, from October 2010 to October 2011, who underwent upper gastrointestinal 
      endoscopy and whose biopsies were positive for infection with H. pylori. At the 
      end, 81 patients were included in the order of biopsy result arrival to fill the 
      quota of each group. The first group with 42 patients underwent triple therapy 
      with clarithromycin and the second group with 39 patients underwent therapy with 
      levofloxacin, amoxicillin and a PPI. The patients' age ranged between 23 and 
      76years, the average being 49.5. The predominant sex was female, at 72.84%. Both 
      treatments lasted for 10days and the patients were clinically re-evaluated 15days 
      after their conclusion and programmed for a second endoscopy to verify H. pylori 
      eradication. RESULTS: Among the 42 patients in the control group, there were 14 
      eradication failures with 33.33% resistance to clarithromycin. Among the 39 
      patients in the experimental group, two eradication failures with 5.13% 
      resistance to levofloxacin were observed. The chi(2) value was 6.96. CONCLUSIONS: 
      Treatment with levofloxacin was more effective than conventional triple therapy. 
      Triple therapy with levofloxacin can be implemented in populations where 
      resistance to clarithromycin has been observed.
CI  - Copyright (c) 2013 Arab Journal of Gastroenterology. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Dib, Jacobo Jr
AU  - Dib J Jr
AD  - Medical Department and Gastroenterology Service at Hospital de Lidice, Caracas, 
      Venezuela. Electronic address: dib.j@hotmail.com.
FAU - Alvarez, Bethseidy
AU  - Alvarez B
FAU - Mendez, Liskie
AU  - Mendez L
FAU - Cruz, Maria E
AU  - Cruz ME
LA  - eng
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
DEP - 20131014
PL  - Egypt
TA  - Arab J Gastroenterol
JT  - Arab journal of gastroenterology : the official publication of the Pan-Arab 
      Association of Gastroenterology
JID - 101298363
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Proton Pump Inhibitors)
RN  - 6GNT3Y5LMF (Levofloxacin)
RN  - 804826J2HU (Amoxicillin)
RN  - H1250JIK0A (Clarithromycin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Amoxicillin/*therapeutic use
MH  - Anti-Bacterial Agents/*therapeutic use
MH  - Clarithromycin/*therapeutic use
MH  - Drug Resistance, Bacterial
MH  - Drug Therapy, Combination/methods
MH  - Female
MH  - Helicobacter Infections/*drug therapy/microbiology
MH  - *Helicobacter pylori
MH  - Humans
MH  - Levofloxacin/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Venezuela
MH  - Young Adult
OTO - NOTNLM
OT  - Helicobacter pylori
OT  - Levofloxacin
EDAT- 2013/11/12 06:00
MHDA- 2014/10/31 06:00
CRDT- 2013/11/12 06:00
PHST- 2011/11/21 00:00 [received]
PHST- 2012/05/11 00:00 [revised]
PHST- 2012/12/10 00:00 [accepted]
PHST- 2013/11/12 06:00 [entrez]
PHST- 2013/11/12 06:00 [pubmed]
PHST- 2014/10/31 06:00 [medline]
AID - S1687-1979(13)00127-5 [pii]
AID - 10.1016/j.ajg.2013.09.001 [doi]
PST - ppublish
SO  - Arab J Gastroenterol. 2013 Sep;14(3):123-5. doi: 10.1016/j.ajg.2013.09.001. Epub 
      2013 Oct 14.