PMID- 24210347
OWN - NLM
STAT- MEDLINE
DCOM- 20140730
LR  - 20161020
IS  - 1528-3933 (Electronic)
IS  - 1091-8531 (Linking)
VI  - 17
IP  - 6
DP  - 2013 Dec
TI  - Using autofluorescence to detect optic nerve head drusen in children.
PG  - 568-71
LID - S1091-8531(13)00319-4 [pii]
LID - 10.1016/j.jaapos.2013.07.012 [doi]
AB  - PURPOSE: To assess the efficacy of using autofluorescence to identify optic nerve 
      head drusen (ONHD) in children. METHODS: We conducted a cross-sectional, 
      descriptive study of subjects <18 years of age with possible pseudopapilledema 
      due to ONHD. B-scan ultrasonography was considered the gold standard diagnostic 
      technique. All participants underwent an extensive ophthalmic examination that 
      included fundus color photography, autofluorescence analysis, and B-scan 
      echography. ONHD were classified as visible or hidden. Autofluorescence images 
      were analyzed by three observers who were masked to the results of B-scan 
      ultrasonography. RESULTS: A total of 24 children with pseudopapilledema were 
      included. B-scan ultrasonography confirmed ONHD in 32 eyes of 18 patients (9 
      boys). Mean patient age was 12 years (range, 7-17 years). ONHD was bilateral in 
      14 patients; unilateral in 4. The majority of the drusen were hidden (26 of 32 
      eyes). Analysis of autofluorescence patterns identified the drusen in 94% of 
      cases (30 of 32 eyes): visible, 100%; hidden, 92%. Interobserver agreement was 
      high (kappa = 0.91, kappa = 0.96, kappa = 0.89). CONCLUSIONS: In this study cohort, 
      autofluorescence proved a safe, fast, and reliable technique for identifying ONHD 
      in children.
CI  - Copyright (c) 2013 American Association for Pediatric Ophthalmology and Strabismus. 
      Published by Mosby, Inc. All rights reserved.
FAU - Gili, Pablo
AU  - Gili P
AD  - Ophthalmology Unit, Hospital Universitario Fundacion Alcorcon, Madrid, Spain; 
      Health Sciences Faculty, Universidad Europea, Madrid, Spain. Electronic address: 
      pgili@fhalcorcon.es.
FAU - Flores-Rodriguez, Patricia
AU  - Flores-Rodriguez P
FAU - Yanguela, Julio
AU  - Yanguela J
FAU - Herreros Fernandez, Maria Luisa
AU  - Herreros Fernandez ML
LA  - eng
PT  - Journal Article
DEP - 20131107
PL  - United States
TA  - J AAPOS
JT  - Journal of AAPOS : the official publication of the American Association for 
      Pediatric Ophthalmology and Strabismus
JID - 9710011
RN  - Pseudopapilledema
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Eye Diseases, Hereditary/*diagnosis/etiology
MH  - Female
MH  - *Fluorescein Angiography
MH  - Humans
MH  - Male
MH  - Observer Variation
MH  - Optic Disk Drusen/complications/*diagnosis
MH  - Optic Nerve Diseases/*diagnosis/etiology
MH  - Optical Imaging/*methods
EDAT- 2013/11/12 06:00
MHDA- 2014/07/31 06:00
CRDT- 2013/11/12 06:00
PHST- 2013/04/05 00:00 [received]
PHST- 2013/07/16 00:00 [revised]
PHST- 2013/07/20 00:00 [accepted]
PHST- 2013/11/12 06:00 [entrez]
PHST- 2013/11/12 06:00 [pubmed]
PHST- 2014/07/31 06:00 [medline]
AID - S1091-8531(13)00319-4 [pii]
AID - 10.1016/j.jaapos.2013.07.012 [doi]
PST - ppublish
SO  - J AAPOS. 2013 Dec;17(6):568-71. doi: 10.1016/j.jaapos.2013.07.012. Epub 2013 Nov 
      7.