PMID- 24210352
OWN - NLM
STAT- MEDLINE
DCOM- 20140128
LR  - 20231213
IS  - 1097-4180 (Electronic)
IS  - 1074-7613 (Print)
IS  - 1074-7613 (Linking)
VI  - 39
IP  - 5
DP  - 2013 Nov 14
TI  - A beneficial role for immunoglobulin E in host defense against honeybee venom.
PG  - 963-75
LID - S1074-7613(13)00439-1 [pii]
LID - 10.1016/j.immuni.2013.10.005 [doi]
AB  - Allergies are widely considered to be misdirected type 2 immune responses, in 
      which immunoglobulin E (IgE) antibodies are produced against any of a broad range 
      of seemingly harmless antigens. However, components of insect venoms also can 
      sensitize individuals to develop severe IgE-associated allergic reactions, 
      including fatal anaphylaxis, upon subsequent venom exposure. We found that mice 
      injected with amounts of honeybee venom similar to that which could be delivered 
      in one or two stings developed a specific type 2 immune response that increased 
      their resistance to subsequent challenge with potentially lethal amounts of the 
      venom. Our data indicate that IgE antibodies and the high affinity IgE receptor, 
      FcepsilonRI, were essential for such acquired resistance to honeybee venom. The 
      evidence that IgE-dependent immune responses against venom can enhance survival 
      in mice supports the hypothesis that IgE, which also contributes to allergic 
      disorders, has an important function in protection of the host against noxious 
      substances.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Marichal, Thomas
AU  - Marichal T
AD  - Department of Pathology, Stanford University School of Medicine, Stanford, CA 
      94305, USA.
FAU - Starkl, Philipp
AU  - Starkl P
FAU - Reber, Laurent L
AU  - Reber LL
FAU - Kalesnikoff, Janet
AU  - Kalesnikoff J
FAU - Oettgen, Hans C
AU  - Oettgen HC
FAU - Tsai, Mindy
AU  - Tsai M
FAU - Metz, Martin
AU  - Metz M
FAU - Galli, Stephen J
AU  - Galli SJ
LA  - eng
GR  - R01 AI023990/AI/NIAID NIH HHS/United States
GR  - CA072074/CA/NCI NIH HHS/United States
GR  - J 3399/FWF_/Austrian Science Fund FWF/Austria
GR  - AI070813/AI/NIAID NIH HHS/United States
GR  - AI023990/AI/NIAID NIH HHS/United States
GR  - R01 CA072074/CA/NCI NIH HHS/United States
GR  - UL1 RR025744/RR/NCRR NIH HHS/United States
GR  - UL1 TR001085/TR/NCATS NIH HHS/United States
GR  - R37 AI023990/AI/NIAID NIH HHS/United States
GR  - R01 AI070813/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20131024
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (Bee Venoms)
RN  - 0 (Epitopes)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Receptors, IgE)
RN  - 0 (Viper Venoms)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
CIN - Nat Rev Immunol. 2013 Dec;13(12):843. PMID: 24202657
CIN - Immunity. 2013 Nov 14;39(5):803-5. PMID: 24238337
MH  - Anaphylaxis/etiology/immunology/prevention & control
MH  - Animals
MH  - Bee Venoms/administration & dosage/immunology/therapeutic use/*toxicity
MH  - Desensitization, Immunologic
MH  - Dose-Response Relationship, Immunologic
MH  - Epitopes
MH  - Female
MH  - Hypersensitivity/*immunology
MH  - Immunization, Passive
MH  - Immunoglobulin E/biosynthesis/*immunology
MH  - Immunoglobulin G/biosynthesis/immunology
MH  - Mast Cells/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Models, Immunological
MH  - Receptors, IgE/immunology
MH  - Daboia
MH  - Th2 Cells/immunology
MH  - Viper Venoms/immunology/toxicity
PMC - PMC4164235
MID - NIHMS624567
EDAT- 2013/11/12 06:00
MHDA- 2014/01/29 06:00
PMCR- 2014/11/14
CRDT- 2013/11/12 06:00
PHST- 2013/05/02 00:00 [received]
PHST- 2013/08/21 00:00 [accepted]
PHST- 2013/11/12 06:00 [entrez]
PHST- 2013/11/12 06:00 [pubmed]
PHST- 2014/01/29 06:00 [medline]
PHST- 2014/11/14 00:00 [pmc-release]
AID - S1074-7613(13)00439-1 [pii]
AID - 10.1016/j.immuni.2013.10.005 [doi]
PST - ppublish
SO  - Immunity. 2013 Nov 14;39(5):963-75. doi: 10.1016/j.immuni.2013.10.005. Epub 2013 
      Oct 24.