PMID- 24212037
OWN - NLM
STAT- MEDLINE
DCOM- 20140623
LR  - 20131111
IS  - 1878-3619 (Electronic)
IS  - 0959-2989 (Linking)
VI  - 24
IP  - 1
DP  - 2014
TI  - Tumor classification based on orthogonal linear discriminant analysis.
PG  - 1399-405
LID - 10.3233/BME-130944 [doi]
AB  - Gene expression profiles have great potential for accurate tumor diagnosis. It is 
      expected to enable us to diagnose tumors precisely and systematically, and also 
      bring the researchers of machine learning two challenges, the curse of 
      dimensionality and the small sample size problems. We propose a manifold learning 
      based dimensional reduction algorithm named orthogonal local discriminant 
      embedding (O-LDE) and apply it to tumor classification. Comparing with the 
      classical local discriminant embedding (LDE), O-LDE aims to obtain an orthogonal 
      linear projection matrix by solving an optimization problem. After being 
      projected into a low-dimensional subspace by O-LDE, the data points of the same 
      class maintain their intrinsic neighbor relations, whereas the neighboring points 
      of the different classes are far from each other. Experimental results on a 
      public tumor dataset validate the effectiveness and feasibility of the proposed 
      algorithm.
FAU - Wang, Huiya
AU  - Wang H
AD  - Department of Mathematics, Northwest University, Xi'an 710069, China.
FAU - Zhang, Shanwen
AU  - Zhang S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Biomed Mater Eng
JT  - Bio-medical materials and engineering
JID - 9104021
SB  - IM
MH  - Algorithms
MH  - Artificial Intelligence
MH  - Computer Simulation
MH  - Databases, Factual
MH  - *Discriminant Analysis
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Leukemia/classification/*diagnosis
MH  - Models, Theoretical
MH  - Neoplasms/classification/*diagnosis/*genetics
OTO - NOTNLM
OT  - Tumor classification
OT  - local discriminant embedding (LDE)
OT  - orthogonal local discriminant embedding (O-LDE)
EDAT- 2013/11/12 06:00
MHDA- 2014/06/24 06:00
CRDT- 2013/11/12 06:00
PHST- 2013/11/12 06:00 [entrez]
PHST- 2013/11/12 06:00 [pubmed]
PHST- 2014/06/24 06:00 [medline]
AID - Q866H7141TJ82016 [pii]
AID - 10.3233/BME-130944 [doi]
PST - ppublish
SO  - Biomed Mater Eng. 2014;24(1):1399-405. doi: 10.3233/BME-130944.