PMID- 24212181
OWN - NLM
STAT- MEDLINE
DCOM- 20140619
LR  - 20220409
IS  - 2072-6651 (Electronic)
IS  - 2072-6651 (Linking)
VI  - 5
IP  - 11
DP  - 2013 Nov 7
TI  - Antibacterial and antidiarrheal activities of plant products against 
      enterotoxinogenic Escherichia coli.
PG  - 2009-41
LID - 10.3390/toxins5112009 [doi]
AB  - Enterotoxigenic Escherichia coli (ETEC) produces two types of enterotoxins: 
      heat-labile (LT) and heat-stable (STa and STb). These molecules are involved in 
      the induction of secretory diarrhea in animals including humans. This condition 
      is currently treated using a fluid replacement therapy and antibiotics. This 
      treatment is often not available to people in developing countries, and several 
      die from the condition provoke by ETEC. Over the years, plants and plant extracts 
      have been use as traditional medicine to treat various gastrointestinal ailments 
      including diarrhea. Many of these plant products have been claimed to be active 
      against diarrhea, however few have been extensively studied. The main objective 
      of this review was to gather the scattered information on the antidiarrheal 
      activities reported for various plant products on ETEC. This includes two major 
      effects: (1) The inhibitory effect on bacterial growth or viability and (2) The 
      interference with ETEC enterotoxins activity upon the intestinal epithelium. We 
      will focus on plant products and extracts for which we have major indications of 
      their biological activity against ETEC and their enterotoxins. Because Vibrio 
      cholerae toxin (CT) is structurally, antigenically and mechanistically related to 
      LT, it will also be discussed in this review.
FAU - Dubreuil, J Daniel
AU  - Dubreuil JD
AD  - Departement de pathologie et microbiologie, Faculte de medecine veterinaire, 
      Universite de Montreal, Quebec, Canada. daniel.dubreuil@umontreal.ca.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20131107
PL  - Switzerland
TA  - Toxins (Basel)
JT  - Toxins
JID - 101530765
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Antidiarrheals)
RN  - 0 (Enterotoxins)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/*pharmacology
MH  - Antidiarrheals/*pharmacology
MH  - Diarrhea/microbiology
MH  - Enterotoxigenic Escherichia coli/*drug effects
MH  - Enterotoxins/toxicity
MH  - Humans
MH  - Plant Extracts/*pharmacology
PMC - PMC3847712
EDAT- 2013/11/12 06:00
MHDA- 2014/06/20 06:00
PMCR- 2013/11/01
CRDT- 2013/11/12 06:00
PHST- 2013/09/17 00:00 [received]
PHST- 2013/10/25 00:00 [revised]
PHST- 2013/10/30 00:00 [accepted]
PHST- 2013/11/12 06:00 [entrez]
PHST- 2013/11/12 06:00 [pubmed]
PHST- 2014/06/20 06:00 [medline]
PHST- 2013/11/01 00:00 [pmc-release]
AID - toxins5112009 [pii]
AID - toxins-05-02009 [pii]
AID - 10.3390/toxins5112009 [doi]
PST - epublish
SO  - Toxins (Basel). 2013 Nov 7;5(11):2009-41. doi: 10.3390/toxins5112009.