PMID- 24212565
OWN - NLM
STAT- MEDLINE
DCOM- 20151026
LR  - 20231213
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 3
DP  - 2013 Nov 11
TI  - Involvement of TrkB- and p75(NTR)-signaling pathways in two contrasting forms of 
      long-lasting synaptic plasticity.
PG  - 3185
LID - 10.1038/srep03185 [doi]
LID - 3185
AB  - The repetition of experience is often necessary to establish long-lasting memory. 
      However, the cellular mechanisms underlying this repetition-dependent 
      consolidation of memory remain unclear. We previously observed in organotypic 
      slice cultures of the rodent hippocampus that repeated inductions of long-term 
      potentiation (LTP) led to a slowly developing long-lasting synaptic enhancement 
      coupled with synaptogenesis. We also reported that repeated inductions of 
      long-term depression (LTD) produced a long-lasting synaptic suppression coupled 
      with synapse elimination. We proposed these phenomena as useful in vitro models 
      for analyzing repetition-dependent consolidation. Here, we hypothesized that the 
      enhancement and suppression are mediated by the brain-derived neurotrophic factor 
      (BDNF)-TrkB signaling pathway and the proBDNF-p75(NTR) pathway, respectively. 
      When we masked the respective pathways, reversals of the enhancement and 
      suppression resulted. These results suggest the alternative activation of the 
      p75(NTR) pathway by BDNF under TrkB-masking conditions and of the TrkB pathway by 
      proBDNF under p75(NTR)-masking conditions, thus supporting the aforementioned 
      hypothesis.
FAU - Sakuragi, Shigeo
AU  - Sakuragi S
AD  - Department of Neuroscience, Osaka University Graduate School of Frontier 
      Biosciences, Suita 565-0871 Osaka, Japan.
FAU - Tominaga-Yoshino, Keiko
AU  - Tominaga-Yoshino K
FAU - Ogura, Akihiko
AU  - Ogura A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131111
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Antibodies)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 0 (Ngfr protein, mouse)
RN  - 1F7A44V6OU (Colforsin)
RN  - 534-82-7 (Methoxyhydroxyphenylglycol)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - UEH9K539KJ (3,4-dihydroxyphenylglycol)
SB  - IM
MH  - Animals
MH  - Antibodies/immunology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Colforsin/pharmacology
MH  - Excitatory Postsynaptic Potentials/drug effects
MH  - Hippocampus/metabolism
MH  - In Vitro Techniques
MH  - Long-Term Potentiation/drug effects/*physiology
MH  - Long-Term Synaptic Depression/drug effects/*physiology
MH  - Methoxyhydroxyphenylglycol/analogs & derivatives/pharmacology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Receptor, trkB/immunology/*metabolism
MH  - Receptors, Nerve Growth Factor/*metabolism
MH  - Signal Transduction
PMC - PMC3822391
EDAT- 2013/11/12 06:00
MHDA- 2015/10/27 06:00
PMCR- 2013/11/11
CRDT- 2013/11/12 06:00
PHST- 2013/09/03 00:00 [received]
PHST- 2013/10/25 00:00 [accepted]
PHST- 2013/11/12 06:00 [entrez]
PHST- 2013/11/12 06:00 [pubmed]
PHST- 2015/10/27 06:00 [medline]
PHST- 2013/11/11 00:00 [pmc-release]
AID - srep03185 [pii]
AID - 10.1038/srep03185 [doi]
PST - epublish
SO  - Sci Rep. 2013 Nov 11;3:3185. doi: 10.1038/srep03185.