PMID- 24213225
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131111
LR  - 20211021
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 4
IP  - 1
DP  - 2012 Jan 20
TI  - Diagnosis and Treatment of Gastrinomas in Multiple Endocrine Neoplasia Type 1 
      (MEN-1).
PG  - 39-54
LID - 10.3390/cancers4010039 [doi]
AB  - Multiple endocrine neoplasia type 1 (MEN-1) is a rare autosomal-dominant disease. 
      It is associated with a broad range of endocrine tumours, most frequently arising 
      in the parathyroid glands, the pituitary and the pancreas. Most neuroendocrine 
      tumours will be diagnosed in the pancreas as non-functioning neuroendocrine 
      tumours or insulinomas. Forty-two percent of the patients will develop a 
      gastrin-secreting neuroendocrine tumour, a gastrinoma. Gastrinomas in MEN-1 tend 
      to be small, multiple and preferentially located in the duodenum. This paper will 
      focus on the specific characteristics of gastrinomas in the setting of MEN-1 
      compared to sporadic gastrinomas. The developments in understanding the 
      tumorigenesis of these tumours and the consequences for diagnosis and therapy 
      will be discussed.
FAU - Plockinger, Ursula
AU  - Plockinger U
AD  - Interdisziplinares Stoffwechsel-Centrum: Endokrinologie, Diabetes und 
      Metabolismus, Kompetenzzentrum Seltene Stoffwechselkrankheiten, 
      Charite-Universitatsmedizin Berlin, Campus Virchow-Klinikum, Berlin 13353, 
      Germany. ursula.ploeckinger@charite.de.
LA  - eng
PT  - Journal Article
DEP - 20120120
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC3712689
EDAT- 2012/01/01 00:00
MHDA- 2012/01/01 00:01
PMCR- 2012/01/20
CRDT- 2013/11/12 06:00
PHST- 2011/12/01 00:00 [received]
PHST- 2012/01/07 00:00 [revised]
PHST- 2012/01/12 00:00 [accepted]
PHST- 2013/11/12 06:00 [entrez]
PHST- 2012/01/01 00:00 [pubmed]
PHST- 2012/01/01 00:01 [medline]
PHST- 2012/01/20 00:00 [pmc-release]
AID - cancers4010039 [pii]
AID - cancers-04-00039 [pii]
AID - 10.3390/cancers4010039 [doi]
PST - epublish
SO  - Cancers (Basel). 2012 Jan 20;4(1):39-54. doi: 10.3390/cancers4010039.