PMID- 24213321
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131111
LR  - 20240318
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 4
IP  - 2
DP  - 2012 May 7
TI  - Gastroenteropancreatic neuroendocrine tumors in multiple endocrine neoplasia type 
      1.
PG  - 504-22
LID - 10.3390/cancers4020504 [doi]
AB  - We reviewed the literature about entero-pancreatic neuroendocrine tumors in 
      Multiple Endocrine Neoplasia type 1 syndrome (MEN1) to clarify their demographic 
      features, localization imaging, practice, and appropriate therapeutical 
      strategies, analyzing the current approach to entero-pancreatic neuroendocrine 
      tumors in MEN1. Despite the fact that hyperparathyroidism is usually the first 
      manifestation of MEN1, the penetrance of these tumors is similar. They are 
      characterized by multiplicity of lesions, variable expression of the tumors, and 
      propensity for malignant degeneration. Both the histological type and the size of 
      MEN1 neuroendocrine tumors correlate with malignancy. Monitoring of pancreatic 
      peptides and use of imaging exams allow early diagnosis and prompt surgical 
      treatment, resulting in prevention of metastatic disease and improvement of 
      long-term survival. Surgery is often the treatment of choice for 
      MEN1-neuroendocrine tumors. The rationale for surgical approach is to curtail 
      malignant progression of the disease, and to cure the associated biochemical 
      syndrome, should it be present.
FAU - Tonelli, Francesco
AU  - Tonelli F
AD  - Department of Clinical Physiopathology, Surgical Unit, Medical School, University 
      of Florence, Largo Brambilla n degrees  3, Florence 50134, Italy. f.tonelli@dfc.unifi.it.
FAU - Giudici, Francesco
AU  - Giudici F
FAU - Giusti, Francesca
AU  - Giusti F
FAU - Brandi, Maria Luisa
AU  - Brandi ML
LA  - eng
PT  - Journal Article
DEP - 20120507
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC3712700
EDAT- 2012/01/01 00:00
MHDA- 2012/01/01 00:01
PMCR- 2012/05/07
CRDT- 2013/11/12 06:00
PHST- 2012/02/17 00:00 [received]
PHST- 2012/04/10 00:00 [revised]
PHST- 2012/04/18 00:00 [accepted]
PHST- 2013/11/12 06:00 [entrez]
PHST- 2012/01/01 00:00 [pubmed]
PHST- 2012/01/01 00:01 [medline]
PHST- 2012/05/07 00:00 [pmc-release]
AID - cancers4020504 [pii]
AID - cancers-04-00504 [pii]
AID - 10.3390/cancers4020504 [doi]
PST - epublish
SO  - Cancers (Basel). 2012 May 7;4(2):504-22. doi: 10.3390/cancers4020504.