PMID- 24213563
OWN - NLM
STAT- MEDLINE
DCOM- 20140428
LR  - 20220330
IS  - 1470-7926 (Electronic)
IS  - 1351-0711 (Linking)
VI  - 71
IP  - 4
DP  - 2014 Apr
TI  - Interactions between SERPINA1 PiMZ genotype, occupational exposure and lung 
      function decline.
PG  - 234-40
LID - 10.1136/oemed-2013-101592 [doi]
AB  - OBJECTIVES: We evaluated interactions between SERPINA1 PiMZ genotype, associated 
      with intermediate alpha1-antitrysin deficiency, with outdoor particulate matter </=10 
      microm (PM10), and occupational exposure to vapours, dusts, gases and fumes (VGDF), 
      and their effects on annual change in lung function. METHODS: Pre-bronchodilator 
      spirometry was performed in 3739 adults of the Swiss Cohort Study on Air 
      Pollution and Lung Disease in Adults (SAPALDIA) for whom SERPINA1 genotypes were 
      available. At baseline in 1991, participants were aged 18-62 years; follow-up 
      measurements were conducted from 2001 to 2003. In linear mixed regression models 
      of annual change in lung function, multiplicative interactions were evaluated 
      between PiMZ genotype (PiMM as reference) and change in PM10 (mug/m(3)), and VGDF 
      exposure (high-level, low-level or no exposure as reference) during follow-up. 
      RESULTS: Annual declines in forced expiratory flow at 25-75% of forced vital 
      capacity (FEF25-75%) (-82 mL/s, 95% CI -125 to -39) and forced expiratory volume 
      in 1 s over forced vital capacity (FEV1/FVC) (-0.3%, 95% CI -0.6% to 0.0%) in 
      association with VGDF exposure were observed only in PiMZ carriers 
      (Pinteraction<0.0001 and Pinteraction=0.03, respectively). A three-way 
      interaction between PiMZ genotype, smoking and VGDF exposure was identified such 
      that VGDF-associated FEF25-75% decline was observed only in ever smoking PiMZ 
      carriers (Pinteraction=0.01). No interactions were identified between PiMZ 
      genotype and outdoor PM10. CONCLUSIONS: SERPINA1 PiMZ genotype, in combination 
      with smoking, modified the association between occupational VGDF exposure and 
      longitudinal change in lung function, suggesting that interactions between these 
      factors are relevant for lung function decline. These novel findings warrant 
      replication in larger studies.
FAU - Mehta, A J
AU  - Mehta AJ
AD  - Swiss Tropical and Public Health Institute, Basel, Switzerland.
FAU - Thun, G A
AU  - Thun GA
FAU - Imboden, M
AU  - Imboden M
FAU - Ferrarotti, I
AU  - Ferrarotti I
FAU - Keidel, D
AU  - Keidel D
FAU - Kunzli, N
AU  - Kunzli N
FAU - Kromhout, H
AU  - Kromhout H
FAU - Miedinger, D
AU  - Miedinger D
FAU - Phuleria, H
AU  - Phuleria H
FAU - Rochat, T
AU  - Rochat T
FAU - Russi, E W
AU  - Russi EW
FAU - Schindler, C
AU  - Schindler C
FAU - Schwartz, J
AU  - Schwartz J
FAU - Vermeulen, R
AU  - Vermeulen R
FAU - Luisetti, M
AU  - Luisetti M
FAU - Probst-Hensch, N
AU  - Probst-Hensch N
CN  - SAPALDIA team
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131108
PL  - England
TA  - Occup Environ Med
JT  - Occupational and environmental medicine
JID - 9422759
RN  - 0 (Dust)
RN  - 0 (Gases)
RN  - 0 (Particulate Matter)
RN  - 0 (SERPINA1 protein, human)
RN  - 0 (alpha 1-Antitrypsin)
SB  - IM
CIN - Occup Environ Med. 2014 Apr;71(4):229-30. PMID: 24399069
MH  - Adolescent
MH  - Adult
MH  - Air Pollution/adverse effects
MH  - Cohort Studies
MH  - Dust
MH  - Female
MH  - Follow-Up Studies
MH  - Forced Expiratory Volume
MH  - Gases
MH  - Genetic Predisposition to Disease
MH  - *Genotype
MH  - Humans
MH  - Lung/*physiopathology
MH  - Lung Diseases/etiology/*genetics/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Occupational Diseases/etiology/*genetics/physiopathology
MH  - Occupational Exposure/*adverse effects
MH  - Particulate Matter/*adverse effects
MH  - Smoking/adverse effects
MH  - Spirometry
MH  - Switzerland
MH  - Vital Capacity
MH  - Young Adult
MH  - alpha 1-Antitrypsin/*genetics
MH  - alpha 1-Antitrypsin Deficiency/complications/genetics
EDAT- 2013/11/12 06:00
MHDA- 2014/04/29 06:00
CRDT- 2013/11/12 06:00
PHST- 2013/11/12 06:00 [entrez]
PHST- 2013/11/12 06:00 [pubmed]
PHST- 2014/04/29 06:00 [medline]
AID - oemed-2013-101592 [pii]
AID - 10.1136/oemed-2013-101592 [doi]
PST - ppublish
SO  - Occup Environ Med. 2014 Apr;71(4):234-40. doi: 10.1136/oemed-2013-101592. Epub 
      2013 Nov 8.