PMID- 24213624
OWN - NLM
STAT- MEDLINE
DCOM- 20140929
LR  - 20140203
IS  - 1530-0447 (Electronic)
IS  - 0031-3998 (Linking)
VI  - 75
IP  - 1-1
DP  - 2014 Jan
TI  - Protective effects of maternal nutritional supplementation with lactoferrin on 
      growth and brain metabolism.
PG  - 51-61
LID - 10.1038/pr.2013.199 [doi]
AB  - BACKGROUND: Intrauterine growth restriction (IUGR) is a major risk factor for 
      both perinatal and long-term morbidity. Bovine lactoferrin (bLf) is a major milk 
      glycoprotein considered as a pleiotropic functional nutrient. The impact of 
      maternal supplementation with bLf on IUGR-induced sequelae, including inadequate 
      growth and altered cerebral development, remains unknown. METHODS: IUGR was 
      induced through maternal dexamethasone infusion (100 mug/kg during last 
      gestational week) in rats. Maternal supplementation with bLf (0.85% in food 
      pellet) was provided during both gestation and lactation. Pup growth was 
      monitored, and Pup brain metabolism and gene expression were studied using in 
      vivo (1)H NMR spectroscopy, quantitative PCR, and microarray in the hippocampus 
      at postnatal day (PND)7. RESULTS: Maternal bLf supplementation did not change 
      gestational weight but increased the birth body weight of control pups (4%) with 
      no effect on the IUGR pups. Maternal bLf supplementation allowed IUGR pups to 
      recover a normalized weight at PND21 (weaning) improving catch-up growth. 
      Significantly altered levels of brain metabolites (gamma-aminobutyric acid, 
      glutamate, N-acetylaspartate, and N-acetylaspartylglutamate) and transcripts 
      (brain-derived neurotrophic factor (BDNF), divalent metal transporter 1 (DMT-1), 
      and glutamate receptors) in IUGR pups were normalized with maternal bLf 
      supplementation. CONCLUSION: Our data suggest that maternal bLf supplementation 
      is a beneficial nutritional intervention able to revert some of the IUGR-induced 
      sequelae, including brain hippocampal changes.
FAU - Somm, Emmanuel
AU  - Somm E
AD  - Department of Paediatrics, Division of Development and Growth, University of 
      Geneva School of Medicine, Geneva, Switzerland.
FAU - Larvaron, Pierre
AU  - Larvaron P
AD  - Department of Paediatrics, Division of Development and Growth, University of 
      Geneva School of Medicine, Geneva, Switzerland.
FAU - van de Looij, Yohan
AU  - van de Looij Y
AD  - 1] Department of Paediatrics, Division of Development and Growth, University of 
      Geneva School of Medicine, Geneva, Switzerland [2] Laboratory for Functional and 
      Metabolic Imaging, E cole Polytechnique Federale de Lausanne, Lausanne, 
      Switzerland.
FAU - Toulotte, Audrey
AU  - Toulotte A
AD  - Department of Paediatrics, Division of Development and Growth, University of 
      Geneva School of Medicine, Geneva, Switzerland.
FAU - Chatagner, Alexandra
AU  - Chatagner A
AD  - Department of Paediatrics, Division of Development and Growth, University of 
      Geneva School of Medicine, Geneva, Switzerland.
FAU - Faure, Magali
AU  - Faure M
AD  - Nestle Research Center, Lausanne, Switzerland.
FAU - Metairon, Sylviane
AU  - Metairon S
AD  - Nestle Research Center, Lausanne, Switzerland.
FAU - Mansourian, Robert
AU  - Mansourian R
AD  - Nestle Research Center, Lausanne, Switzerland.
FAU - Raymond, Frederic
AU  - Raymond F
AD  - Nestle Research Center, Lausanne, Switzerland.
FAU - Gruetter, Rolf
AU  - Gruetter R
AD  - Laboratory for Functional and Metabolic Imaging, E cole Polytechnique Federale de 
      Lausanne, Lausanne, Switzerland.
FAU - Wang, Bing
AU  - Wang B
AD  - 1] Nestle Research Center, Lausanne, Switzerland [2] School of Animal and 
      Veterinary Science, Charles Sturt University, New South Wales, Australia.
FAU - Sizonenko, Stephane V
AU  - Sizonenko SV
AD  - Department of Paediatrics, Division of Development and Growth, University of 
      Geneva School of Medicine, Geneva, Switzerland.
FAU - Huppi, Petra S
AU  - Huppi PS
AD  - Department of Paediatrics, Division of Development and Growth, University of 
      Geneva School of Medicine, Geneva, Switzerland.
LA  - eng
PT  - Journal Article
DEP - 20131108
PL  - United States
TA  - Pediatr Res
JT  - Pediatric research
JID - 0100714
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - EC 3.4.21.- (Lactoferrin)
SB  - IM
MH  - Animals
MH  - Body Weight/drug effects
MH  - Brain/*drug effects/metabolism
MH  - Dexamethasone/administration & dosage
MH  - *Dietary Supplements
MH  - Female
MH  - Fetal Growth Retardation/metabolism/prevention & control
MH  - Gene Expression/drug effects
MH  - Growth/*drug effects
MH  - Lactation
MH  - Lactoferrin/*administration & dosage/pharmacology
MH  - Polymerase Chain Reaction
MH  - Pregnancy
MH  - Rats
MH  - Weight Gain/drug effects
EDAT- 2013/11/12 06:00
MHDA- 2014/09/30 06:00
CRDT- 2013/11/12 06:00
PHST- 2013/03/28 00:00 [received]
PHST- 2013/06/24 00:00 [accepted]
PHST- 2013/11/12 06:00 [entrez]
PHST- 2013/11/12 06:00 [pubmed]
PHST- 2014/09/30 06:00 [medline]
AID - pr2013199 [pii]
AID - 10.1038/pr.2013.199 [doi]
PST - ppublish
SO  - Pediatr Res. 2014 Jan;75(1-1):51-61. doi: 10.1038/pr.2013.199. Epub 2013 Nov 8.