PMID- 24213955
OWN - NLM
STAT- MEDLINE
DCOM- 20140829
LR  - 20220408
IS  - 1552-6844 (Electronic)
IS  - 1545-9683 (Linking)
VI  - 28
IP  - 2
DP  - 2014 Feb
TI  - Intensive rehabilitation increases BDNF serum levels in parkinsonian patients: a 
      randomized study.
PG  - 163-8
LID - 10.1177/1545968313508474 [doi]
AB  - BACKGROUND: Exercise may decrease the risk of Parkinson's disease (PD) in humans 
      and reduce PD symptoms in animal models. The beneficial effects have been linked 
      to increased levels of neurotrophic factors. OBJECTIVE: We examined whether 
      intensive rehabilitation treatment reduces motor disability in patients in the 
      early stages of PD and increases brain-derived neurotrophic factor (BDNF) serum 
      levels. METHODS: Thirty participants in the early stages of PD treated with 
      rasagiline were randomly assigned to 3 hours of rehabilitation treatment that 
      included aerobic exercise for 28 days (Group 1) or to not therapy (control; Group 
      2). BDNF serum levels were assessed at time T0 (baseline, before treatment), T1 
      (10 days), T2 (20 days), and T3 (28 days). At T0 and T3, we assessed the Unified 
      Parkinson's Disease Rating Scale (UPDRS) III in both groups, as well as the UPDRS 
      II and total, Berg Balance Scale, and 6-minute walking test only in Group 1. 
      RESULTS: BDNF levels significantly increased at T1 in Group 1, an increase that 
      was maintained throughout the treatment period. At T3 compared to T0, UPDRS III 
      scores significantly improved in Group 1 along with scores for UPDRS II, total, 
      Berg Balance Scale, and 6-minute walking test. CONCLUSIONS: Intensive 
      rehabilitation treatment increases the BDNF levels and improves PD signs in 
      patients in the early stages of the disease. These results are in line with 
      studies on animal models of PD and healthy subjects.
FAU - Frazzitta, Giuseppe
AU  - Frazzitta G
AD  - 1"Moriggia-Pelascini" Hospital, Gravedona ed Uniti, Italy.
FAU - Maestri, Roberto
AU  - Maestri R
FAU - Ghilardi, Maria Felice
AU  - Ghilardi MF
FAU - Riboldazzi, Giulio
AU  - Riboldazzi G
FAU - Perini, Michele
AU  - Perini M
FAU - Bertotti, Gabriella
AU  - Bertotti G
FAU - Boveri, Natalia
AU  - Boveri N
FAU - Buttini, Sara
AU  - Buttini S
FAU - Lombino, Franco Luis
AU  - Lombino FL
FAU - Uccellini, Davide
AU  - Uccellini D
FAU - Turla, Marinella
AU  - Turla M
FAU - Pezzoli, Gianni
AU  - Pezzoli G
FAU - Comi, Cristoforo
AU  - Comi C
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20131108
PL  - United States
TA  - Neurorehabil Neural Repair
JT  - Neurorehabilitation and neural repair
JID - 100892086
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Exercise Therapy
MH  - Humans
MH  - Parkinson Disease/*blood/*rehabilitation
OTO - NOTNLM
OT  - BDNF
OT  - Parkinson's disease
OT  - neuroplasticity
OT  - rehabilitation
EDAT- 2013/11/12 06:00
MHDA- 2014/08/30 06:00
CRDT- 2013/11/12 06:00
PHST- 2013/11/12 06:00 [entrez]
PHST- 2013/11/12 06:00 [pubmed]
PHST- 2014/08/30 06:00 [medline]
AID - 1545968313508474 [pii]
AID - 10.1177/1545968313508474 [doi]
PST - ppublish
SO  - Neurorehabil Neural Repair. 2014 Feb;28(2):163-8. doi: 10.1177/1545968313508474. 
      Epub 2013 Nov 8.