PMID- 24214952
OWN - NLM
STAT- MEDLINE
DCOM- 20140825
LR  - 20131220
IS  - 1552-6941 (Electronic)
IS  - 1534-7346 (Linking)
VI  - 12
IP  - 4
DP  - 2013 Dec
TI  - Association of variant rs7903146 (C/T) single nucleotide polymorphism of TCF7L2 
      gene with impairment in wound healing among north Indian type 2 diabetes 
      population: a case-control study.
PG  - 310-5
LID - 10.1177/1534734613504435 [doi]
AB  - The variants of transcription factor 7-like 2 (TCF7L2) gene have been shown to be 
      associated with type 2 diabetes mellitus (T2DM) and its several secondary 
      complications. Here, we aimed to examine the possible role of one of the common 
      variant of this gene, rs7903146 (C/T), with impairment of wound healing in cases 
      with T2DM. A total of 750 individuals, including 322 patients with T2DM and 120 
      patients with diabetic foot ulcers (DFUs) and 308 controls, were analyzed for 
      rs7903146 variant of the TCF7L2 gene. Genotyping was done by polymerase chain 
      reaction-restriction fragment length polymorphism. For rs7903146 variant, TT 
      genotype frequency in patients with DFU was 10.8% and in controls was 5.2%. Risk 
      genotype (TT) frequencies showed statistically significant difference between the 
      DFU patients versus non-DM control group (odds ratio = 2.44, P = .037, 95% 
      confidence interval = 1.05-5.64) compared with nonrisk genotype (CC + CT). In the 
      present study, a positive significant association between DFU and the TT genotype 
      of rs7903146 (C/T) variant of TCF7L2 gene was found.
FAU - Singh, Kanhaiya
AU  - Singh K
AD  - 1Department of Molecular & Human Genetics, Banaras Hindu University, Varanasi, 
      India.
FAU - Agrawal, Neeraj K
AU  - Agrawal NK
FAU - Gupta, Sanjeev K
AU  - Gupta SK
FAU - Singh, Kiran
AU  - Singh K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131109
PL  - United States
TA  - Int J Low Extrem Wounds
JT  - The international journal of lower extremity wounds
JID - 101128359
RN  - 0 (TCF7L2 protein, human)
RN  - 0 (Transcription Factor 7-Like 2 Protein)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - *Diabetes Mellitus, Type 2/complications/ethnology/genetics
MH  - *Diabetic Foot/ethnology/genetics
MH  - Female
MH  - Humans
MH  - India/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Transcription Factor 7-Like 2 Protein/*genetics
MH  - Wound Healing/*genetics
OTO - NOTNLM
OT  - T2DM
OT  - diabetic wound healing impairment
OT  - polymorphism
OT  - rs7903146
OT  - transcription factor 7-like 2 (TCF7L2)
EDAT- 2013/11/12 06:00
MHDA- 2014/08/26 06:00
CRDT- 2013/11/12 06:00
PHST- 2013/11/12 06:00 [entrez]
PHST- 2013/11/12 06:00 [pubmed]
PHST- 2014/08/26 06:00 [medline]
AID - 1534734613504435 [pii]
AID - 10.1177/1534734613504435 [doi]
PST - ppublish
SO  - Int J Low Extrem Wounds. 2013 Dec;12(4):310-5. doi: 10.1177/1534734613504435. 
      Epub 2013 Nov 9.