PMID- 24215977
OWN - NLM
STAT- MEDLINE
DCOM- 20140929
LR  - 20240318
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 258
DP  - 2014 Jan 31
TI  - Differential cortical neurotrophin and cytogenetic adaptation after voluntary 
      exercise in normal and amnestic rats.
PG  - 131-46
LID - S0306-4522(13)00935-4 [pii]
LID - 10.1016/j.neuroscience.2013.10.075 [doi]
AB  - Voluntary exercise (VEx) has profound effects on neural and behavioral 
      plasticity, including recovery of CNS trauma and disease. However, the unique 
      regional cortical adaption to VEx has not been elucidated. In a series of 
      experiments, we first examined whether VEx would restore and retain neurotrophin 
      levels in several cortical regions (frontal cortex [FC], retrosplenial cortex 
      [RSC], occipital cortex [OC]) in an animal model (pyrithiamine-induced thiamine 
      deficiency [PTD]) of the amnestic disorder Wernicke-Korsakoff syndrome. In 
      addition, we assessed the time-dependent effect of VEx to rescue performance on a 
      spontaneous alternation task. Following 2-weeks of VEx or stationary housing 
      conditions (Stat), rats were behaviorally tested and brains were harvested either 
      the day after VEx (24-h) or after an additional 2-week period (2-wk). In both 
      control pair-fed (PF) rats and PTD rats, all neurotrophin levels (brain-derived 
      neurotrophic factor [BDNF], nerve growth factor [NGF], and vascular endothelial 
      growth factor) increased at the 24-h period after VEx in the FC and RSC, but not 
      OC. Two-weeks following VEx, BDNF remained elevated in both FC and RSC, whereas 
      NGF remained elevated in only the FC. Interestingly, VEx only recovered cognitive 
      performance in amnestic rats when there was an additional 2-wk adaptation period 
      after VEx. Given this unique temporal profile, Experiment 2 examined the cortical 
      cytogenetic responses in all three cortical regions following a 2-wk adaptation 
      period after VEx. In healthy (PF) rats, VEx increased the survival of progenitor 
      cells in both the FC and RSC, but only increased oligodendrocyte precursor cells 
      (OLPs) in the FC. Furthermore, VEx had a selective effect of only recovering OLPs 
      in the FC in PTD rats. These data reveal the therapeutic potential of exercise to 
      restore cortical plasticity in the amnestic brain, and that the FC is one of the 
      most responsive cortical regions to VEx.
CI  - Copyright (c) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Hall, J M
AU  - Hall JM
AD  - Behavioral Neuroscience Program, Department of Psychology, Binghamton 
      University-State University of New York, United States.
FAU - Vetreno, R P
AU  - Vetreno RP
AD  - Behavioral Neuroscience Program, Department of Psychology, Binghamton 
      University-State University of New York, United States.
FAU - Savage, L M
AU  - Savage LM
AD  - Behavioral Neuroscience Program, Department of Psychology, Binghamton 
      University-State University of New York, United States. Electronic address: 
      lsavage@binghamton.edu.
LA  - eng
GR  - R01 NS054272/NS/NINDS NIH HHS/United States
GR  - 054272-S1/PHS HHS/United States
GR  - 054272/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20131109
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 5JB3029BJ7 (Pyrithiamine)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Amnesia/*physiopathology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cell Survival
MH  - Cerebral Cortex/*physiopathology
MH  - Cytogenetic Analysis
MH  - Frontal Lobe/physiopathology
MH  - Housing, Animal
MH  - Male
MH  - Motor Activity/*physiology
MH  - Nerve Growth Factor/metabolism
MH  - Nerve Growth Factors/*metabolism
MH  - Occipital Lobe/physiopathology
MH  - Oligodendroglia/physiology
MH  - Pyrithiamine
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stem Cells/physiology
MH  - Thiamine Deficiency/physiopathology
MH  - Time Factors
MH  - Vascular Endothelial Growth Factor A/metabolism
PMC - PMC3947177
MID - NIHMS540401
OTO - NOTNLM
OT  - 5'-bromo-2'-deoxyuridine
OT  - ACh
OT  - ANOVA
OT  - BDNF
OT  - BrdU
OT  - ELISA
OT  - FC
OT  - GFAP
OT  - HRP
OT  - IVD
OT  - NG2
OT  - NGF
OT  - OC
OT  - OLPs
OT  - PBS
OT  - PF
OT  - PFC
OT  - PTD
OT  - RSC
OT  - SSC
OT  - TBS
OT  - Tris HCl-buffered saline
OT  - VEGF
OT  - VEx
OT  - WKS
OT  - Wernicke-Korsakoff syndrome
OT  - acetylcholine
OT  - amnesia
OT  - analysis of variance
OT  - brain-derived neurotrophic factor
OT  - cortex
OT  - cytogenesis
OT  - enzyme-linked immunosorbent assay
OT  - exercise
OT  - frontal cortex
OT  - glial fibrillary acidic protein
OT  - growth factors
OT  - horseradish peroxidase
OT  - intraventricular distance
OT  - nerve growth factor
OT  - occipital cortex
OT  - oligodendrocyte precursor cells
OT  - pair-fed
OT  - phosphate-buffered saline
OT  - prefrontal cortex
OT  - proteoglycan neuron-glia 2 protein
OT  - pyrithiamine-induced thiamine deficiency
OT  - retrosplenial cortex
OT  - saline-sodium citrate
OT  - vascular endothelial growth factor
OT  - voluntary exercise
EDAT- 2013/11/13 06:00
MHDA- 2014/09/30 06:00
PMCR- 2015/01/31
CRDT- 2013/11/13 06:00
PHST- 2013/09/12 00:00 [received]
PHST- 2013/10/30 00:00 [revised]
PHST- 2013/10/30 00:00 [accepted]
PHST- 2013/11/13 06:00 [entrez]
PHST- 2013/11/13 06:00 [pubmed]
PHST- 2014/09/30 06:00 [medline]
PHST- 2015/01/31 00:00 [pmc-release]
AID - S0306-4522(13)00935-4 [pii]
AID - 10.1016/j.neuroscience.2013.10.075 [doi]
PST - ppublish
SO  - Neuroscience. 2014 Jan 31;258:131-46. doi: 10.1016/j.neuroscience.2013.10.075. 
      Epub 2013 Nov 9.