PMID- 24216497
OWN - NLM
STAT- MEDLINE
DCOM- 20150511
LR  - 20181202
IS  - 1547-3317 (Electronic)
IS  - 0587-2871 (Linking)
VI  - 50
IP  - 1
DP  - 2014 Jan-Feb
TI  - The cardiovascular effects of sevoflurane and isoflurane after premedication of 
      healthy dogs undergoing elective surgery.
PG  - 27-35
LID - 10.5326/JAAHA-MS-5963 [doi]
AB  - Sevoflurane and isoflurane are commonly used in veterinary anesthesia. The 
      objective of this prospective, randomized, open-label clinical study was to 
      compare the cardiovascular effects of sevoflurane and isoflurane via direct 
      arterial blood pressure measurements and the lithium dilution cardiac output 
      (LDCO) on premedicated healthy dogs undergoing elective tibial plateau leveling 
      osteotomy (TPLO). Nineteen client-owned dogs were included. All dogs were 
      premedicated with hydromorphone (0.05 mg/kg IV and glycopyrrolate 0.01 mg/kg 
      subcutaneously). Ten dogs were anesthetized with sevoflurane and nine dogs were 
      anesthetized with isoflurane. Eighteen dogs were instrumented with a dorsal pedal 
      arterial catheter, and one dog had a femoral arterial catheter. All dogs had 
      continuous, direct systolic (SAP), diastolic (DAP), and mean arterial (MAP) blood 
      pressure readings as well as heart rate (HR), cardiac output (CO), cardiac index 
      (CI), systemic vascular resistance (SVR), systemic vascular resistance index 
      (SVRI), stroke volume variation (SVV), and pulse pressure variation (PPV) 
      recorded q 5 min during the surgical procedure. There was no significant 
      statistical difference in all parameters between the sevoflurane and isoflurane 
      treatment groups. Both sevoflurane and isoflurane inhalant anesthetics appear to 
      have similar hemodynamic effects when used as part of a multimodal anesthetic 
      protocol in premedicated healthy dogs undergoing an elective surgical procedure.
FAU - Abed, Janan M
AU  - Abed JM
AD  - Department of Emergency and Critical Care, Veterinary Specialty Hospital of San 
      Diego, San Diego, CA; and Department of Small Animal Medicine and Surgery, 
      College of Veterinary Medicine, University of Georgia, Athens, GA (B.B.).
FAU - Pike, Fred S
AU  - Pike FS
FAU - Clare, Monica C
AU  - Clare MC
FAU - Brainard, Benjamin M
AU  - Brainard BM
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20131111
PL  - United States
TA  - J Am Anim Hosp Assoc
JT  - Journal of the American Animal Hospital Association
JID - 0415027
RN  - 0 (Anesthetics, Inhalation)
RN  - 0 (Methyl Ethers)
RN  - 38LVP0K73A (Sevoflurane)
RN  - CYS9AKD70P (Isoflurane)
SB  - IM
MH  - Anesthetics, Inhalation/administration & dosage/*pharmacology
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Dogs/*physiology
MH  - Elective Surgical Procedures/veterinary
MH  - Heart Rate/drug effects
MH  - Isoflurane/administration & dosage/*pharmacology
MH  - Methyl Ethers/administration & dosage/*pharmacology
MH  - Osteotomy/veterinary
MH  - Premedication/veterinary
MH  - Prospective Studies
MH  - Sevoflurane
MH  - Treatment Outcome
EDAT- 2013/11/13 06:00
MHDA- 2015/05/12 06:00
CRDT- 2013/11/13 06:00
PHST- 2013/11/13 06:00 [entrez]
PHST- 2013/11/13 06:00 [pubmed]
PHST- 2015/05/12 06:00 [medline]
AID - JAAHA-MS-5963 [pii]
AID - 10.5326/JAAHA-MS-5963 [doi]
PST - ppublish
SO  - J Am Anim Hosp Assoc. 2014 Jan-Feb;50(1):27-35. doi: 10.5326/JAAHA-MS-5963. Epub 
      2013 Nov 11.