PMID- 24216543
OWN - NLM
STAT- MEDLINE
DCOM- 20141016
LR  - 20220408
IS  - 1530-0447 (Electronic)
IS  - 0031-3998 (Linking)
VI  - 75
IP  - 2
DP  - 2014 Feb
TI  - Effects on growth and tolerance and hypoallergenicity of an amino acid-based 
      formula with synbiotics.
PG  - 343-51
LID - 10.1038/pr.2013.211 [doi]
AB  - BACKGROUND: To evaluate the effects of an amino acid-based formula (AAF) with 
      synbiotics on growth and tolerance in healthy infants. The hypoallergenicity of 
      this AAF with synbiotics was evaluated in subjects with cow's milk allergy (CMA). 
      METHODS: Study 1: 115 full-term, healthy infants randomly received an AAF with 
      synbiotics or a commercially available AAF for 16 wk. Subjects' weight, length, 
      and head circumference were primary outcome measures. Stool characteristics and 
      gastrointestinal (GI) symptoms were secondary outcome measures. Clinical 
      examinations, dietary intake, clinical laboratory results, and adverse events 
      were recorded. Study 2: hypoallergenicity of the AAF with synbiotics was 
      evaluated in 30 infants and children with immunoglobulin E (IgE)-mediated CMA 
      using a double-blind, placebo-controlled food challenge, and a 7-d feeding 
      period. RESULTS: Study 1: comparable results in growth parameters and tolerance 
      were observed for both groups. Minimal differences were observed in stool 
      characteristics and GI symptoms throughout the study. Study 2: all 30 subjects 
      with IgE-mediated CMA completed the study with no allergic reactions detected to 
      challenges. CONCLUSION: These studies demonstrate that an AAF with synbiotics is 
      safe and well tolerated and promotes normal growth when fed to healthy full-term 
      infants as the sole source of nutrition and is hypoallergenic in subjects with 
      CMA.
FAU - Harvey, Bryan M
AU  - Harvey BM
AD  - Children's Investigational Research Program, LLC (CHIRP), Bentonville, Arkansas.
FAU - Langford, Jane E
AU  - Langford JE
AD  - Research & Development, Nutricia Advanced Medical Nutrition, Liverpool, UK.
FAU - Harthoorn, Lucien F
AU  - Harthoorn LF
AD  - Research & Development, Nutricia Advanced Medical Nutrition, Liverpool, UK.
FAU - Gillman, Sherwin A
AU  - Gillman SA
AD  - Children's Hospital of Orange County, Orange, California.
FAU - Green, Todd D
AU  - Green TD
AD  - Division of Pulmonary Medicine, Allergy & Immunology, Department of Pediatrics, 
      Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
FAU - Schwartz, Richard H
AU  - Schwartz RH
AD  - Department of Pediatrics, Inova Fairfax Hospital for Children, Falls Church, 
      Virginia.
FAU - Burks, A Wesley
AU  - Burks AW
AD  - Division of Pediatric Allergy & Immunology, Duke University Medical Center, 
      Durham, North Carolina.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20131111
PL  - United States
TA  - Pediatr Res
JT  - Pediatric research
JID - 0100714
RN  - 0 (Allergens)
RN  - 0 (Amino Acids)
RN  - 0 (Oligosaccharides)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens
MH  - Amino Acids/*chemistry
MH  - Animals
MH  - Bifidobacterium/metabolism
MH  - Cattle
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Immune Tolerance
MH  - Immunoglobulin E/chemistry
MH  - Infant
MH  - Infant Formula/administration & dosage/*chemistry
MH  - Male
MH  - Milk Hypersensitivity/*immunology
MH  - Oligosaccharides/chemistry
MH  - Probiotics/chemistry
MH  - *Synbiotics
EDAT- 2013/11/13 06:00
MHDA- 2014/10/17 06:00
CRDT- 2013/11/13 06:00
PHST- 2012/12/17 00:00 [received]
PHST- 2013/05/30 00:00 [accepted]
PHST- 2013/11/13 06:00 [entrez]
PHST- 2013/11/13 06:00 [pubmed]
PHST- 2014/10/17 06:00 [medline]
AID - pr2013211 [pii]
AID - 10.1038/pr.2013.211 [doi]
PST - ppublish
SO  - Pediatr Res. 2014 Feb;75(2):343-51. doi: 10.1038/pr.2013.211. Epub 2013 Nov 11.