PMID- 24217842 OWN - NLM STAT- MEDLINE DCOM- 20141009 LR - 20220310 IS - 1972-6007 (Electronic) IS - 0009-9074 (Linking) VI - 164 IP - 5 DP - 2013 TI - Hepatitis C virus infection and type 2 diabetes. PG - e393-404 LID - 10.7417/CT.2013.1620 [doi] AB - Hepatitis C virus (HCV) infection and Type 2 diabetes mellitus (T2DM) are two worldwide, major public health problems with increasing complication and mortality rates. Many epidemiological studies have demonstrated the significant association between T2DM and chronic HCV infection. In this paper we have reviewed the increasing evidence linking HCV infection and DM in more than one field (epidemiology, pathogenesis, clinical aspects, prevention and treatment). We have considered T2DM, acute and chronic HCV infection, and cirrhotic patients. Moreover, we have considered some particular populations, solid organ transplant recipients or HCV/human immunodeficiency virus (HIV) coinfected patients. In the final part we have analyzed the potential effect of the association between HCV infection and the development of DM in term of outcome and possibilities for prevention and treatment. FAU - Fallahi, P AU - Fallahi P AD - Department of Clinical and Experimental Medicine, University of Pisa, Pisa. FAU - Ferrari, S M AU - Ferrari SM FAU - Colaci, M AU - Colaci M FAU - Ruffilli, I AU - Ruffilli I FAU - Vita, R AU - Vita R FAU - Azzi, A AU - Azzi A FAU - Ferri, C AU - Ferri C FAU - Antonelli, A AU - Antonelli A FAU - Ferrannini, E AU - Ferrannini E LA - eng PT - Journal Article PT - Review PL - Italy TA - Clin Ter JT - La Clinica terapeutica JID - 0372604 RN - 0 (Immunosuppressive Agents) RN - IY9XDZ35W2 (Glucose) SB - IM MH - Autoimmune Diseases/etiology/immunology MH - Diabetes Mellitus, Type 1/etiology MH - Diabetes Mellitus, Type 2/prevention & control/*virology MH - Disease Susceptibility MH - Genotype MH - Glucose/metabolism MH - HIV Infections/epidemiology MH - Hepacivirus/genetics MH - Hepatitis C, Chronic/*complications/immunology/metabolism/prevention & control MH - Humans MH - Immunosuppressive Agents/adverse effects/therapeutic use MH - Liver/metabolism MH - Liver Cirrhosis/complications/metabolism/virology MH - Organ Transplantation MH - Postoperative Complications/etiology MH - Prevalence MH - Prognosis MH - Thyroid Diseases/etiology EDAT- 2013/11/13 06:00 MHDA- 2014/10/10 06:00 CRDT- 2013/11/13 06:00 PHST- 2013/11/13 06:00 [entrez] PHST- 2013/11/13 06:00 [pubmed] PHST- 2014/10/10 06:00 [medline] AID - 10.7417/CT.2013.1620 [doi] PST - ppublish SO - Clin Ter. 2013;164(5):e393-404. doi: 10.7417/CT.2013.1620.