PMID- 24218295
OWN - NLM
STAT- MEDLINE
DCOM- 20150724
LR  - 20211021
IS  - 1559-0267 (Electronic)
IS  - 1080-0549 (Linking)
VI  - 47
IP  - 3
DP  - 2014 Dec
TI  - Immunoglobulin E-binding epitopes of mite allergens: from characterization to 
      immunotherapy.
PG  - 344-53
LID - 10.1007/s12016-013-8396-5 [doi]
AB  - House dust mites and storage mites produce a number of allergens that can induce 
      hypersensitivity reactions in humans and result in allergic diseases like asthma, 
      rhinitis, and dermatitis. Recent advances in identifying and characterizing these 
      allergens--and, in particular, their immunoglobulin E (IgE)-binding 
      epitopes--have produced a wealth of knowledge. Here, methods for identifying 
      IgE-binding epitopes, from immunoassays to in silico approaches, are summarized 
      and placed in context with the identification of epitopes of mite allergens, 
      particularly from the Dermatophagoides spp. major allergen groups 1 and 2. 
      Finally, the transfer of this information to the clinical development and 
      application of new diagnostic and immunotherapeutic approaches is discussed. 
      While progress in recent years has built on the specific immunotherapies 
      established decades ago, much work remains to be done to mitigate mite allergic 
      disease. Future studies should seek to identify epitopes for mite species beyond 
      Dermatophagoides and for minor allergens. Efforts in translational medicine 
      should use the current epitope data to develop modified allergens for 
      immunotherapy.
FAU - Cui, Yubao
AU  - Cui Y
AD  - Department of Laboratory Medicine, Yancheng Health Vocational and Technical 
      College, Jiefangnan Road 263, Yancheng, 224006, Jiangsu, People's Republic of 
      China, ybcui1975@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Clin Rev Allergy Immunol
JT  - Clinical reviews in allergy & immunology
JID - 9504368
RN  - 0 (Antigens, Dermatophagoides)
RN  - 0 (Epitopes, B-Lymphocyte)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Antigens, Dermatophagoides/*immunology
MH  - Desensitization, Immunologic/methods
MH  - Epitopes, B-Lymphocyte/*immunology
MH  - Humans
MH  - Hypersensitivity/etiology/*immunology/prevention & control/therapy
MH  - Immunoglobulin E/*immunology
MH  - Mites/*immunology
EDAT- 2013/11/13 06:00
MHDA- 2015/07/25 06:00
CRDT- 2013/11/13 06:00
PHST- 2013/11/13 06:00 [entrez]
PHST- 2013/11/13 06:00 [pubmed]
PHST- 2015/07/25 06:00 [medline]
AID - 10.1007/s12016-013-8396-5 [doi]
PST - ppublish
SO  - Clin Rev Allergy Immunol. 2014 Dec;47(3):344-53. doi: 10.1007/s12016-013-8396-5.