PMID- 24218591
OWN - NLM
STAT- MEDLINE
DCOM- 20140127
LR  - 20211021
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 110
IP  - 48
DP  - 2013 Nov 26
TI  - Fungal-derived semiochemical 1-octen-3-ol disrupts dopamine packaging and causes 
      neurodegeneration.
PG  - 19561-6
LID - 10.1073/pnas.1318830110 [doi]
AB  - Parkinson disease (PD) is the most common movement disorder and, although the 
      exact causes are unknown, recent epidemiological and experimental studies 
      indicate that several environmental agents may be significant risk factors. To 
      date, these suspected environmental risk factors have been man-made chemicals. In 
      this report, we demonstrate via genetic, biochemical, and immunological studies 
      that the common volatile fungal semiochemical 1-octen-3-ol reduces dopamine 
      levels and causes dopamine neuron degeneration in Drosophila melanogaster. 
      Overexpression of the vesicular monoamine transporter (VMAT) rescued the dopamine 
      toxicity and neurodegeneration, whereas mutations decreasing VMAT and tyrosine 
      hydroxylase exacerbated toxicity. Furthermore, 1-octen-3-ol also inhibited uptake 
      of dopamine in human cell lines expressing the human plasma membrane dopamine 
      transporter (DAT) and human VMAT ortholog, VMAT2. These data demonstrate that 
      1-octen-3-ol exerts toxicity via disruption of dopamine homeostasis and may 
      represent a naturally occurring environmental agent involved in parkinsonism.
FAU - Inamdar, Arati A
AU  - Inamdar AA
AD  - Department of Plant Biology and Pathology, Rutgers, The State University of New 
      Jersey, New Brunswick, NJ 08901.
FAU - Hossain, Muhammad M
AU  - Hossain MM
FAU - Bernstein, Alison I
AU  - Bernstein AI
FAU - Miller, Gary W
AU  - Miller GW
FAU - Richardson, Jason R
AU  - Richardson JR
FAU - Bennett, Joan Wennstrom
AU  - Bennett JW
LA  - eng
GR  - P30ES019776/ES/NIEHS NIH HHS/United States
GR  - R01ES015991/ES/NIEHS NIH HHS/United States
GR  - P30 ES019776/ES/NIEHS NIH HHS/United States
GR  - R21NS072097/NS/NINDS NIH HHS/United States
GR  - U01 NS079249/NS/NINDS NIH HHS/United States
GR  - T32 ES012870/ES/NIEHS NIH HHS/United States
GR  - R21 NS072097/NS/NINDS NIH HHS/United States
GR  - P50NS071669/NS/NINDS NIH HHS/United States
GR  - P30 ES005022/ES/NIEHS NIH HHS/United States
GR  - R01 ES015991/ES/NIEHS NIH HHS/United States
GR  - P50 NS071669/NS/NINDS NIH HHS/United States
GR  - P30ES005022/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20131111
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Octanols)
RN  - 0 (Pheromones)
RN  - VTD58H1Z2X (Dopamine)
RN  - WXB511GE38 (1-octen-3-ol)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Chromatography, High Pressure Liquid
MH  - Dopamine/*metabolism
MH  - Dopaminergic Neurons/*drug effects
MH  - Drosophila
MH  - Microscopy, Confocal
MH  - Movement/drug effects
MH  - Nerve Degeneration/*chemically induced
MH  - Octanols/*toxicity
MH  - Pheromones/*toxicity
PMC - PMC3845153
OTO - NOTNLM
OT  - building-related illness
OT  - mold
OT  - mushroom alcohol
COIS- The authors declare no conflict of interest.
EDAT- 2013/11/13 06:00
MHDA- 2014/01/28 06:00
PMCR- 2014/05/26
CRDT- 2013/11/13 06:00
PHST- 2013/11/13 06:00 [entrez]
PHST- 2013/11/13 06:00 [pubmed]
PHST- 2014/01/28 06:00 [medline]
PHST- 2014/05/26 00:00 [pmc-release]
AID - 1318830110 [pii]
AID - 201318830 [pii]
AID - 10.1073/pnas.1318830110 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19561-6. doi: 
      10.1073/pnas.1318830110. Epub 2013 Nov 11.