PMID- 24218628
OWN - NLM
STAT- MEDLINE
DCOM- 20150115
LR  - 20161125
IS  - 1741-7899 (Electronic)
IS  - 1470-1626 (Linking)
VI  - 147
IP  - 4
DP  - 2014
TI  - No association between exposure to perfluorinated compounds and congenital 
      cryptorchidism: a nested case-control study among 215 boys from Denmark and 
      Finland.
PG  - 411-7
LID - 10.1530/REP-13-0444 [doi]
AB  - Geographical differences in the occurrence of diseases in male reproductive 
      organs, including malformation in reproductive tract, between Denmark and Finland 
      have been reported. The reason for these differences is unknown, but differences 
      in exposure to chemicals with endocrine-disrupting abilities have been suggested. 
      Among these chemicals are perfluoro-alkylated substances (PFASs), a group of 
      water- and grease-repellent chemicals used in outdoor clothes, cookware, food 
      packaging, and textiles. In this study, we, therefore, investigated differences 
      in PFAS exposure levels between Denmark and Finland and the association between 
      cord blood PFAS levels and congenital cryptorchidism. Boys from a joint ongoing 
      prospective birth cohort study were included. We analyzed PFAS levels in cord 
      blood serum samples collected from 29 Danish boys with congenital cryptorchidism, 
      30 healthy Danish matched controls recruited from 1997 to 2001, 30 Finnish cases, 
      and 78 Finnish healthy matched controls recruited from 1997 to 1999. 
      Additionally, 48 Finnish cases recruited from 2000 to 2002 were included. 
      Perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) were 
      detected in all the 215 Danish and Finnish cord blood samples with significantly 
      higher levels being observed in the Danish samples (medians: PFOA, 2.6 ng/ml and 
      PFOS, 9.1 ng/ml) than in the Finnish samples (medians: PFOA, 2.1 ng/ml and PFOS, 
      5.2 ng/ml). We found no associations between cord blood PFOA and PFOS levels and 
      congenital cryptorchidism after adjustment for confounders. Our data indicate 
      that women in Denmark and Finland are generally exposed to PFOA and PFOS but 
      there are differences in exposure levels between countries. We found no 
      statistically significant association between cord blood PFOA and PFOS levels and 
      congenital cryptorchidism; however, our study was small and larger studies are 
      warranted.
FAU - Vesterholm Jensen, Dorte
AU  - Vesterholm Jensen D
AD  - Department of Environmental Medicine, University of Southern Denmark, J.B. 
      Winslows Vej 17, 5000 Odense, Denmark.
FAU - Christensen, Jeppe
AU  - Christensen J
FAU - Virtanen, Helena E
AU  - Virtanen HE
FAU - Skakkebaek, Niels E
AU  - Skakkebaek NE
FAU - Main, Katharina M
AU  - Main KM
FAU - Toppari, Jorma
AU  - Toppari J
FAU - Veje, Christine W
AU  - Veje CW
FAU - Andersson, Anna-Maria
AU  - Andersson AM
FAU - Nielsen, Flemming
AU  - Nielsen F
FAU - Grandjean, Philippe
AU  - Grandjean P
FAU - Jensen, Tina Kold
AU  - Jensen TK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140302
PL  - England
TA  - Reproduction
JT  - Reproduction (Cambridge, England)
JID - 100966036
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Caprylates)
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Fluorocarbons)
RN  - 947VD76D3L (perfluorooctanoic acid)
RN  - 9H2MAI21CL (perfluorooctane sulfonic acid)
SB  - IM
MH  - Adult
MH  - Alkanesulfonic Acids/*blood
MH  - Caprylates/*blood
MH  - Case-Control Studies
MH  - Cryptorchidism/blood/chemically induced/*epidemiology
MH  - Denmark/epidemiology
MH  - Endocrine Disruptors/*blood
MH  - Female
MH  - Fetal Blood/*chemistry
MH  - Finland/epidemiology
MH  - Fluorocarbons/*blood
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*blood/*epidemiology
EDAT- 2013/11/13 06:00
MHDA- 2015/01/16 06:00
CRDT- 2013/11/13 06:00
PHST- 2013/11/13 06:00 [entrez]
PHST- 2013/11/13 06:00 [pubmed]
PHST- 2015/01/16 06:00 [medline]
AID - REP-13-0444 [pii]
AID - 10.1530/REP-13-0444 [doi]
PST - epublish
SO  - Reproduction. 2014 Mar 2;147(4):411-7. doi: 10.1530/REP-13-0444. Print 2014.