PMID- 24218877
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20131113
IS  - 1000-8020 (Print)
IS  - 1000-8020 (Linking)
VI  - 42
IP  - 5
DP  - 2013 Sep
TI  - [Association between polymorphism of FOXA1 gene and type 2 diabetes].
PG  - 736-40
AB  - OBJECTIVE: To detect the relationship between FOXA1 gene polymorphism and type 2 
      diabetes mellitus (T2DM). METHODS: The techniques of mass chromatographic 
      analysis were used to detect the polymorphism of FOXA1 gene in 190 patients with 
      T2DM and 193 healthy control persons without T2DM. We used the software SPSS 13.0 
      for statistical analysis. RESULTS: There was no significant difference between 
      the case and control group about sex and age distribution. The distribution of 
      genotypic frequency in control group consistented with the Hardy-Weinberg law. 
      The frequency of the TT, TC and CC genotype in case were 76.5%, 19.3% and 4.3%. 
      The frequency of the TT, TC and CC genotype in control were 78.1%, 20.3% and 
      1.6%. There was no significant difference between the case and control group 
      about genotype frequency (chi2 = 2.49, P = 0.287). There may be no significant 
      difference between the TC, TG, HDL-C, LDL-C level and genotypes of rs7144658 in 
      mutant. CONCLUSION: There may be no significant relationship between the 
      polymorphism of FOXA1 gene and T2DM. Genic mutation on rs7144658 may not affect 
      the lipid level in type 2 diabetics.
FAU - Lu, Le
AU  - Lu L
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Jilin 
      University,Changchun 130021,China. lvle2009wl@126.com
FAU - Li, Yong
AU  - Li Y
FAU - Qiao, Yichun
AU  - Qiao Y
FAU - Tang, Yuan
AU  - Tang Y
FAU - Yan, Zhihui
AU  - Yan Z
FAU - Cheng, Yi
AU  - Cheng Y
FAU - Liu, Yawen
AU  - Liu Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Wei Sheng Yan Jiu
JT  - Wei sheng yan jiu = Journal of hygiene research
JID - 9426367
RN  - 0 (FOXA1 protein, human)
RN  - 0 (Hepatocyte Nuclear Factor 3-alpha)
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - China
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Female
MH  - Genotype
MH  - Hepatocyte Nuclear Factor 3-alpha/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mutation
MH  - *Polymorphism, Single Nucleotide
EDAT- 2013/11/14 06:00
MHDA- 2015/03/31 06:00
CRDT- 2013/11/14 06:00
PHST- 2013/11/14 06:00 [entrez]
PHST- 2013/11/14 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
PST - ppublish
SO  - Wei Sheng Yan Jiu. 2013 Sep;42(5):736-40.