PMID- 24218881
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20171116
IS  - 1000-8020 (Print)
IS  - 1000-8020 (Linking)
VI  - 42
IP  - 5
DP  - 2013 Sep
TI  - [Effect of in utero and lactational exposure to a binary mixture of 3,3',4,4', 
      5-pentachlorobiphenyl (PCB126) and 2,3',4,4',5-pentachlorobiphenyl (PCB118) on 
      reproductive function in male rat offsprings].
PG  - 758-63
AB  - OBJECTIVE: To examine the effects of in utero and lactational exposure to a 
      binary mixture of 3,3',4,4',5-pentachlorobiphenyl (PCB126) and 
      2,3',4,4',5-pentachlorobiphenyl (PCB118) on reproductive function in male rat 
      offsprings. METHODS: Pregnant Sprague-Dawley rats were given the mixture by 
      gavage with 0.096, 0.96, 4.8 microg toxic equivalency (TEQ)/kg on gestational day 
      (GD) 15. The effects of mixture on F1 rats were observed. RESULTS: The male 
      offspring in the 0.96 and 4.8 microg TEQ/kg groups showed significant inhibition 
      of body weight gain, anogenital distance (AGD) and sperm counts. Mixtures at 4.8 
      microg TEQ/kg significantly reduced weights of accessory sex organs, but only 
      prostate weight reduced at 0.96 microg TEQ/kg. There were no significant 
      differences on serum testosterone. CONCLUSION: The results demonstrated that in 
      utero and lactational exposure to the mixtures of PCB126 and PCB118 affected 
      development of male offspring and impaired adult male offspring reproductive 
      organs.
FAU - Xu, Chengmin
AU  - Xu C
AD  - Institute of Hygiene, Zhejiang Academy of Medical Sciences, Hangzhou 310013, 
      China. xucm@zjams.com.cn
FAU - Chai, Jianrong
AU  - Chai J
FAU - Qian, Yaling
AU  - Qian Y
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Wei Sheng Yan Jiu
JT  - Wei sheng yan jiu = Journal of hygiene research
JID - 9426367
RN  - 2B2AQE8U50 (2,3',4,4',5-pentachlorobiphenyl)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - TSH69IA9XF (3,4,5,3',4'-pentachlorobiphenyl)
SB  - IM
MH  - Animals
MH  - Female
MH  - *Lactation
MH  - Male
MH  - Polychlorinated Biphenyls/*toxicity
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Prostate/drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reproduction/*drug effects
MH  - Sperm Count
MH  - Testis/drug effects
EDAT- 2013/11/14 06:00
MHDA- 2015/03/31 06:00
CRDT- 2013/11/14 06:00
PHST- 2013/11/14 06:00 [entrez]
PHST- 2013/11/14 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
PST - ppublish
SO  - Wei Sheng Yan Jiu. 2013 Sep;42(5):758-63.