PMID- 24219891
OWN - NLM
STAT- MEDLINE
DCOM- 20140821
LR  - 20211021
IS  - 1476-5640 (Electronic)
IS  - 0954-3007 (Linking)
VI  - 68
IP  - 1
DP  - 2014 Jan
TI  - Plasminogen activator inhibitor-1, monocyte chemoattractant protein-1, e-selectin 
      and C-reactive protein levels in response to 4-week very-high-fructose or 
      -glucose diets.
PG  - 97-100
LID - 10.1038/ejcn.2013.228 [doi]
AB  - BACKGROUND/OBJECTIVES: High intake of added sweeteners is considered to have a 
      causal role in the pathogenesis of cardiometabolic disorders. Especially, 
      high-fructose intake is regarded as potentially harmful to cardiometabolic 
      health. It may cause not only weight gain but also low-grade inflammation, which 
      represents an independent risk factor for developing type 2 diabetes and 
      cardiovascular disease. In particular, fructose has been suggested to induce 
      plasminogen activator inhibitor-1 (PAI-1) expression in the liver and to increase 
      circulating inflammatory cytokines. We therefore aimed to investigate, whether 
      high-fructose diet has an impact on PAI-1, monocyte chemoattractant protein-1 
      (MCP-1), e-selectin and C-reactive protein (CRP) concentrations in healthy 
      humans. SUBJECTS/METHODS: We studied 20 participants (12 males and 8 females) of 
      the TUebingen FRuctose Or Glucose study. This is an exploratory, parallel, 
      prospective, randomized, single-blinded, outpatient, hypercaloric, intervention 
      study. The participants had a mean age of 30.9 +/- 2.1 years and a mean body mass 
      index of 26.0 +/- 0.5 kg/m(2) and they received 150 g of either fructose or glucose 
      per day for 4 weeks. RESULTS: There were neither significant changes of PAI-1, 
      MCP-1, e-selectin and CRP after fructose (n=10) and glucose (n=10) intervention 
      nor treatment effects (all P>0.2). Moreover, we did not observe longitudinal 
      associations of the inflammatory parameters with triglycerides, liver fat, 
      visceral fat and body weight in the fructose group. CONCLUSIONS: Temporary 
      high-fructose intake does not seem to cause inflammation in apparently healthy 
      people in this secondary analysis of a small feeding trial.
FAU - Silbernagel, G
AU  - Silbernagel G
AD  - 1] Department of Angiology, Swiss Cardiovascular Center, Inselspital, University 
      of Bern, Bern, Switzerland [2] Division of Endocrinology, Diabetology, 
      Nephrology, Vascular Disease and Clinical Chemistry, Department of Internal 
      Medicine, Eberhard-Karls University, Tubingen, Germany [3] Institute for Diabetes 
      Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the 
      Eberhard-Karls University, Member of the German Center for Diabetes Research 
      (DZD), Tubingen, Germany.
FAU - Machann, J
AU  - Machann J
AD  - Section on Experimental Radiology, Department of Diagnostic and Interventional 
      Radiology, Eberhard-Karls University, Tubingen, Germany.
FAU - Haring, H-U
AU  - Haring HU
AD  - 1] Division of Endocrinology, Diabetology, Nephrology, Vascular Disease and 
      Clinical Chemistry, Department of Internal Medicine, Eberhard-Karls University, 
      Tubingen, Germany [2] Institute for Diabetes Research and Metabolic Diseases 
      (IDM) of the Helmholtz Center Munich at the Eberhard-Karls University, Member of 
      the German Center for Diabetes Research (DZD), Tubingen, Germany.
FAU - Fritsche, A
AU  - Fritsche A
AD  - 1] Division of Endocrinology, Diabetology, Nephrology, Vascular Disease and 
      Clinical Chemistry, Department of Internal Medicine, Eberhard-Karls University, 
      Tubingen, Germany [2] Institute for Diabetes Research and Metabolic Diseases 
      (IDM) of the Helmholtz Center Munich at the Eberhard-Karls University, Member of 
      the German Center for Diabetes Research (DZD), Tubingen, Germany.
FAU - Peter, A
AU  - Peter A
AD  - 1] Division of Endocrinology, Diabetology, Nephrology, Vascular Disease and 
      Clinical Chemistry, Department of Internal Medicine, Eberhard-Karls University, 
      Tubingen, Germany [2] Institute for Diabetes Research and Metabolic Diseases 
      (IDM) of the Helmholtz Center Munich at the Eberhard-Karls University, Member of 
      the German Center for Diabetes Research (DZD), Tubingen, Germany.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20131113
PL  - England
TA  - Eur J Clin Nutr
JT  - European journal of clinical nutrition
JID - 8804070
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (E-Selectin)
RN  - 0 (Nutritive Sweeteners)
RN  - 0 (Plasminogen Activator Inhibitor 1)
RN  - 0 (SELE protein, human)
RN  - 0 (Triglycerides)
RN  - 30237-26-4 (Fructose)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - Body Weight
MH  - C-Reactive Protein/*metabolism
MH  - Chemokine CCL2/*blood
MH  - Diabetes Mellitus, Type 2/physiopathology
MH  - Diet
MH  - E-Selectin/*blood
MH  - Female
MH  - Fructose/administration & dosage/*adverse effects
MH  - Glucose/administration & dosage/*adverse effects
MH  - Humans
MH  - Inflammation/chemically induced
MH  - Intra-Abdominal Fat/metabolism
MH  - Liver/metabolism
MH  - Male
MH  - Nutritive Sweeteners/administration & dosage/adverse effects
MH  - Plasminogen Activator Inhibitor 1/*blood
MH  - Prospective Studies
MH  - Single-Blind Method
MH  - Triglycerides/blood
EDAT- 2013/11/14 06:00
MHDA- 2014/08/22 06:00
CRDT- 2013/11/14 06:00
PHST- 2013/03/26 00:00 [received]
PHST- 2013/08/14 00:00 [revised]
PHST- 2013/09/10 00:00 [accepted]
PHST- 2013/11/14 06:00 [entrez]
PHST- 2013/11/14 06:00 [pubmed]
PHST- 2014/08/22 06:00 [medline]
AID - ejcn2013228 [pii]
AID - 10.1038/ejcn.2013.228 [doi]
PST - ppublish
SO  - Eur J Clin Nutr. 2014 Jan;68(1):97-100. doi: 10.1038/ejcn.2013.228. Epub 2013 Nov 
      13.