PMID- 24222336
OWN - NLM
STAT- MEDLINE
DCOM- 20140317
LR  - 20140113
IS  - 1521-4141 (Electronic)
IS  - 0014-2980 (Linking)
VI  - 43
IP  - 12
DP  - 2013 Dec
TI  - Human dendritic cells - stars in the skin.
PG  - 3147-55
LID - 10.1002/eji.201343790 [doi]
AB  - "A properly functioning adaptive immune system signifies the best features of 
      life. It is diverse beyond compare, tolerant without fail, and capable of 
      behaving appropriately with a myriad of infections and other challenges. 
      Dendritic cells (DCs) are required to explain how this remarkable system is 
      energized and directed." This is a quote by one of the greatest immunologists our 
      community has ever known, and the father of dendritic cells, Ralph Steinman. 
      Steinman's discovery of DCs in 1973 and his subsequent research opened a new 
      field of study within immunology: DC biology and in particular the role of DCs in 
      immune regulation in health and disease. Here, I review themes from our work and 
      others on the complex network of dendritic cells in the skin and discuss the 
      significance of skin DCs in understanding aspects of host defense against 
      infections, the pathology of inflammatory skin diseases, and speculate on the 
      future effective immune-based therapies.
CI  - (c) 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Klechevsky, Eynav
AU  - Klechevsky E
AD  - Department of Pathology and Immunology, Washington University School of Medicine, 
      St. Louis, MO, USA.
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Review
DEP - 20131121
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
SB  - IM
MH  - Dendritic Cells/*immunology/pathology
MH  - Dermatitis/history/*immunology/pathology/therapy
MH  - History, 20th Century
MH  - History, 21st Century
MH  - Humans
MH  - Immunotherapy/methods
MH  - Skin/*immunology/pathology
OTO - NOTNLM
OT  - Human dendritic cells
OT  - Skin
OT  - Vaccines
EDAT- 2013/11/14 06:00
MHDA- 2014/03/19 06:00
CRDT- 2013/11/14 06:00
PHST- 2013/06/10 00:00 [received]
PHST- 2013/09/30 00:00 [revised]
PHST- 2013/10/17 00:00 [accepted]
PHST- 2013/11/14 06:00 [entrez]
PHST- 2013/11/14 06:00 [pubmed]
PHST- 2014/03/19 06:00 [medline]
AID - 10.1002/eji.201343790 [doi]
PST - ppublish
SO  - Eur J Immunol. 2013 Dec;43(12):3147-55. doi: 10.1002/eji.201343790. Epub 2013 Nov 
      21.